2011 Fiscal Year Final Research Report
Imaging diagnosis of multi-step hepatocarcinogenesis : clinical and basic analysis
| Project/Area Number |
21591549
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
MATSUI Osamu 金沢大学, 医学系, 教授 (10019961)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肝細胞癌 / 肝癌多段階発癌 / Gd-EOB-DTPA造影MRI / 早期肝癌 / 悪性度 |
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| Research Abstract |
In accordance with the progression of multi-step hepatocarcinogenesis, the drainage vessels from the tumor changed from hepatic vein to hepatic sinusoids, and then portal vein, and this can be diagnosed by dynamic CT. There was an intensely significant correlation between OATP8 expression and signal intensity on hepatobiliary phase of Gd-EOB-DTPA enhanced MRI. In addition, the expression of OATP8 was decreased from very early stage of hepatocarcinogenesis in accordance with the elevation of grade of malignancy of the tumors. Therefore, EOB-MRI was proved to be extremely useful in the diagnosis of early HCC
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[Journal Article] Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma2011
Author(s)
Kudo M, Imanaka K, Chida N, Nakachi K, Tak WY, Takayama T, Yoon JH, Hori T, Kumada H, Hayashi N, Kaneko S, Tsubouchi H, Suh DJ, Furuse J, Okusaka T, Tanaka K, Matsui O, Wada M, Yamaguchi I, Ohya T, Meinhardt G, Okita K.
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Journal Title
Eur J Cancer
Volume: 47(14)
Pages: 2117-2127
Peer Reviewed
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[Journal Article] The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis : correlation with gadoxetic acid enhanced MR imaging2011
Author(s)
Kitao A, Matsui O, Yoneda N, Kozaka K, Shinmura R, Koda W, Kobayashi S, Gabata T, Zen Y, Yamashita T, Kaneko S, Nakanuma Y.
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Journal Title
Eur Radiol
Volume: 21(10)
Pages: 2056-2066
Peer Reviewed
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[Journal Article] Hepatocellular carcinoma : signal intensity at gadoxetic acid-enhanced MR Imaging-correlation with molecular transporters and histopathologic features2010
Author(s)
Kitao A, Zen Y, Matsui O, Gabata T, Kobayashi S, Koda W, Kozaka K, Yoneda N, Yamashita T, Kaneko S, Nakanuma Y.
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Journal Title
Radiology
Volume: 256(3)
Pages: 817-826
Peer Reviewed
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