2011 Fiscal Year Final Research Report
assessment of central nervous system immunity in a rat glioma model by USPIO-enhanced magnetic resonance imaging
| Project/Area Number |
21591557
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
ITO Ryuta 滋賀医科大学, 医学部, 講師 (80263052)
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| Co-Investigator(Kenkyū-buntansha) |
KITAHARA Hitoshi 滋賀医科大学, 医学部, 助教 (40402721)
JITO Jyunya 滋賀医科大学, 医学部, 助教 (50534161)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 核磁気共鳴画像(MRI) / 脳腫瘍モデル動物 / USPIO造影剤 |
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| Research Abstract |
Microglia has an important role in central nervous system immunity. Histopathologic studies of glioma tissue have revealed high levels of infiltrating microglia. Because microglia is an attractive candidate in immnotherapy for glioma, development of the method to monitor microglial function by magnetic resonance imaging is essential. We showed that ultra-small particles of iron oxide (USPIO) contrast agent could potentially enhance visualization of microglial function although the technique to suppress background signal intensity originating from USPIO outside of microglia should be needed.
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