2011 Fiscal Year Final Research Report
Application of SPECT/CT system in diagnosis of ischemic heart disease
| Project/Area Number |
21591566
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kumamoto University |
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Principal Investigator |
TOMIGUCHI Seiji 熊本大学, 大学院・生命科学研究部, 教授 (20172182)
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| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Akihiro 熊本大学, 生命資源研究・支援センター, 准教授 (20161903)
SHIRAISHI Shinya 熊本大学, 助教 (50433008)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 虚血性心疾患 / SPECT/CT / 減弱補正 / 散乱線補正 / 分解能補正 |
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| Research Abstract |
Fundamental and clinical usefulness of SPECT/CT in the diagnosis of ischemic heart disease was evaluated. Attenuation, scatter and resolution correction for myocardial perfusion SPECT were performed by using CT image. In phantom study, uniformity, defect contrast and count quantification improved with all corrections. In clinical study, sensitivity and specificity in the diagnosis of ischemic heart disease improved with all corrections except decrease in the specificity of LAD territory. However, improvement in the specificity was compensated by using a converted endodiastolic(CED) image. Furthermore,% myocardial radioactivity to the injected dose was considered to be the good index to evaluate the myocardial flow reserve.
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