Establishment of a novel method for imaging diagnosis of Alzheimer's disease

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591578
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Saitama Medical University
• Principal Investigator: MATSUDA Hiroshi 埼玉医科大学, 医学部, 教授 (90173848)
• Co-Investigator(Kenkyū-buntansha): KUJI Ichiei 埼玉医科大学, 医学部, 准教授 (90283142) ; IMABAYASHI Etsuko 埼玉医科大学, 医学部, 講師 (30406491)
• Project Period (FY): 2009 – 2011
• Keywords: 核磁気共鳴画像 / 核医学 / 放射性医薬品・造影剤 / 医用画像工学

Research Abstract

Noninvasive cerebral blood flow measurements using arterial spin labeling(ASL) in MRI and amyloid PET imaging using^<11> C-PiB corrected for partial volume effects were investigated as novel methods for imaging diagnosis of Alzheimer's disease. A software program was developed to statistically analyze an ASL image for a patient as compared with normal database constructed from healthy volunteers. Partial volume correction of amyloid PET image led to accurate quantification of amyloid accumulation in atrophied cerebral cortex in Alzheimer's disease.

Research Products

• [Journal Article] Japanese Alzheimer's Disease Neuroimaging Initiative. Effects of Image Distortion Correction on Voxel-based Morphometry (2012)
  • Author(s): Goto M, Abe O, Kabasawa H, Takao H, Miyati T, Hayashi N, Kurosu T, Iwatsubo T, Yamashita F, Matsuda H, Inano S, Mori H, Kunimatsu A, Aoki S, Ino K, Yano K, Ohtomo K
  • Journal Title: Magn Reson Med Sci Volume: 11 Pages: 27-34
  • Peer Reviewed
• [Journal Article] Molecular neuroimaging in Alzheimer's disease (2012)
  • Author(s): Matsuda H, Imabayashi E
  • Journal Title: Neuroimag Clin N Am Volume: 22 Pages: 57-65
  • Peer Reviewed
• [Journal Article] Pilot data on telmisartan short-term effects on glucose metabolism in the olfactory tract in Alzheimer's disease (2011)
  • Author(s): Imabayashi E, Matsuda H, Yoshimaru K, Kuji I, Seto A, Shimano Y, Ito K, Kikuta D, Shimazu T, Araki N
  • Journal Title: Brain and Behavior Volume: 1 Pages: 63-69
  • Peer Reviewed
• [Journal Article] Hyperperfusion in primary somatosensory region related to somatic hallucination in the elderly (2010)
  • Author(s): Nemoto K, Mizukami K, Hori T, Tachikawa H, Ota M, Takeda T, Ohnishi T, Matsuda H, Asada T
  • Journal Title: Psychiatry Clin Neurosci Volume: 64 Pages: 421-425
  • Peer Reviewed
• [Journal Article] Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone (2010)
  • Author(s): Matsuda H, Imabayashi E, Kuji I, Seto A, Ito K, Kikuta D, Yamada M, Shimano Y, Sato N
  • Journal Title: BMC medical imaging Volume: 10 Pages: 17
  • Peer Reviewed
• [Journal Article] Voxel-based analysis of amyloid positron emission tomography probe[11C] BF-227 uptake in mild cognitive impairment and Alzheimer's disease (2010)
  • Author(s): Shao H, Okamura N, Sugi K, Furumoto S, Furukawa K, Tashiro M, Iwata R, Matsuda H, Kudo Y, Arai H, Fukuda H Yanai K
  • Journal Title: Dement Geriatr Cogn Disord Volume: 30 Pages: 101-111
  • Peer Reviewed
• [Journal Article] White matter abnormalities as a risk factor for postoperative delirium revealed by diffusion tensor imaging (2010)
  • Author(s): Shioiri A, Kurumaji A, Takeuchi T, Matsuda H, Arai H, Nishikawa T
  • Journal Title: Am J Geriatr Psychiatry Volume: 18 Pages: 743-753
  • Peer Reviewed
• [Journal Article] Cortical hypometabolism and hypoperfusion in Parkinson's disease is extensive : probably even at early disease stages (2010)
  • Author(s): Borghammer P, Chakravarty M, Jonsdottir KY, Sato N, Matsuda H, Ito K, Arahata Y, Kato T, Gjedde A
  • Journal Title: Brain Struct Funct Volume: 214 Pages: 303-317
  • Peer Reviewed
• [Journal Article] Arterial spin-labeled MRI study of migraine attacks treated with rizatriptan (2010)
  • Author(s): Kato Y, Araki N, Matsuda H, Ito Y, Suzki C
  • Journal Title: J Headache Pain Volume: 11 Pages: 255-258
  • Peer Reviewed
• [Journal Article] Detection of changes in cerebrospinal fluid space in idiopathic normal pressure hydrocephalus using voxel-based morphometry (2010)
  • Author(s): Yamashita F, Sasaki M, Takahashi S, Matsuda H, Kudo K, Narumi S, Terayama Y, Asada T
  • Journal Title: Neuroradiology Volume: 53 Pages: 381-386
  • Peer Reviewed
• [Journal Article] Automatic voxel-based morphometry of structural MRI by SPM 8 plus DARTEL improves the diagnosis of probable Alzheimer's disease
  • Author(s): Matsuda H, Mizumura S, Nemoto K, Yamashita F, Imabayashi E, Sato N, Asada K
  • Journal Title: Am J Neuroradiol AJNR Volume: (in press)
  • Peer Reviewed
• [Journal Article] Glucose metabolism and gray-matter concentration in apolipoprotein Eε4 positive normal subjects
  • Author(s): Samuraki M, Matsunari I, Chen WP, Shima K, Yanase D, Takeda N, Matsuda H, Yamada M
  • Journal Title: Neurobiol Aging Volume: (in press)
  • Peer Reviewed
• [Journal Article] Posterior cingulate atrophy and metabolic decline in early stage Alzheimer's disease
  • Author(s): Shima K, Matsunari I, Samuraki M, Chen WP, Yanase D, Noguchi-Shinohara M, Takeda N, Ono K, Yoshita M, Miyazaki Y, Matsuda H, Yamada M
  • Journal Title: Neurobiol Aging Volume: (in press)
  • Peer Reviewed
• [Presentation] A new simultateinous geometric and intensity correction method for MRI improves reproducibility in volumetry of brain structures : Japanese Alzheimer's Disease Neurimaging Initiative Study (2011)
  • Author(s): Matsuda H, Yamashita F, Maikusa N, Yuasa T, Tanaka K, Iwatsubo T
  • Organizer: The 97th Scientific Assyembly and Anuual Meeting of RSNA
  • Place of Presentation: Chicago
  • Year and Date: 2011-12-01
• [Presentation] MR-based morphometry of medial temporal regions in patients with Alzheimer's disease and mild cognitive impairment : Japanese Alzheimer's Disease Neuroimaging Initiative Study (2011)
  • Author(s): Nakata Y, Matsuda H, Yamazawa J, Kozono J, Maikusa N
  • Organizer: The 97th Scientific Assembly and Annual Meeting of Radiological Society of North America(RSNA)
  • Place of Presentation: Chicago
  • Year and Date: 2011-11-30
• [Presentation] Development of voxel-based morphometry using brain CT and application to a comparative study between[^<11> C] PiB positive Alzheimer's disease and PiB negative cognitively normal subjects : Japanese Alzheimer's Disease Neurimaging Initiative Study (2011)
  • Author(s): Imabayashi E, Matsuda H, Tabira T, Arima K, Araki N, Ishii K, Iwatsubo T
  • Organizer: The 97th Scientific Assyembly and Anuual Meeting of RSNA
  • Place of Presentation: Chicago
  • Year and Date: 2011-11-30
• [Presentation] Telmisartan inhibits decline of glucose metabolism in olfactory tract in Alzheimer's disease (2011)
  • Author(s): Imabayashi E, Matsuda H, Kuji I, Seto A, Shimano Y, Ito K
  • Organizer: The 58th SNM Annual Meeting
  • Place of Presentation: San Antonio
  • Year and Date: 2011-06-07
• [Presentation] A new technique for the evaluation of both glucose metabolism and atrophy using brain FDG-PET alone (2011)
  • Author(s): Matsuda H, Imabayashi E, Kuji I, Shimano Y
  • Organizer: The 58th SNM Annual Meeting
  • Place of Presentation: San Antonio
  • Year and Date: 2011-06-07
• [Presentation] Evaluation of cerebral atrophy in Alzheimer's disease with MRI (2011)
  • Author(s): Matsuda H
  • Organizer: KoNECT-KITARO Joint Sympoisum
  • Place of Presentation: Seoul
  • Year and Date: 2011-02-21
• [Presentation] Development of a new technique for the evaluation of both perfusion and atrophy using brain SPECT alone (2010)
  • Author(s): Matsuda H, Imabayashi E, Kuji I, Soma T, Seto A, Ito K, Shimano Y
  • Organizer: The 57th SNM Annual Meeting
  • Place of Presentation: Saltlake
  • Year and Date: 2010-06-07
• [Presentation] CT based partial volume correction in(11) C-PiB PET/CT imaging (2010)
  • Author(s): Imabayashi E, Matsuda H, Kuji I, Seto A, Ito K, Shimano Y, Yamada M
  • Organizer: The 57th SNM Annual Meeting
  • Place of Presentation: Saltlake
  • Year and Date: 2010-06-07
• [Book] 今日の精神疾患、治療指針.脳画像検査 (2012)
  • Author(s): 松田博史、樋口輝彦、市川宏伸、神庭重信、朝田隆、中込和幸
  • Total Pages: 692-695
  • Publisher: 医学書院
• [Book] ソフトウェア; eZIS,脳血流SPECTによる精神神経疾患の診断、FDG-PETによるてんかん・脳腫瘍の診断、第3版、最新脳SPECT/PETの臨床 (2012)
  • Author(s): 松田博史、今林悦子、西村恒彦、畑澤順、松田博史
  • Total Pages: 38-42, 98-102, 154-159
  • Publisher: MEDICAL VIEW
• [Book] 精神科研修ノート-精神科で必要な核医学検査 (2011)
  • Author(s): 松田博史
  • Total Pages: 165-169
  • Publisher: 診断と治療社
• [Book] 脳科学エッセンシャル-精神疾患の生物学的理解のために、PET, SPECTと精神疾患,専門医のための精神科臨床リュミエナール (2010)
  • Author(s): 松田博史、神庭重信、加藤忠史
  • Total Pages: 265-267
  • Publisher: 中山書店
• [Book] SPECT, eZIS、VSRAD,正常な加齢・性差、SPECT画像で診るアルツハイマー病.見て診て学ぶ認知症の画像診断 (2010)
  • Author(s): 松田博史、朝田隆
  • Total Pages: 56-63, 101-109, 110-118, 151-165
  • Publisher: 永井書店
• [Patent(Industrial Property Rights)] 医用画像処理方法、装置およびプログラム (2009)
  • Inventor(s): 松葉靖寿、小野徹太郎、後藤智章、笠原邦彦、松田博史
  • Industrial Property Rights Holder: 大日本印刷株式会社
  • Industrial Property Number: 特許、特許出願2009-221391
  • Filing Date: 2009-09-25
• [Patent(Industrial Property Rights)] 診断支援システム、方法およびコンピュータプログラム (2009)
  • Inventor(s): 松田博史、相馬努
  • Industrial Property Rights Holder: 富士フィルムRIファーマ株式会社
  • Industrial Property Number: 特許、特許出願2009-273606
  • Filing Date: 2009-12-01