Establishment of MRI-guided planning in high-dose-rate brachytherapyof prostate cancer

2012 Fiscal Year Final Research Report

• Project/Area Number: 21591582
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kawasaki Medical School
• Principal Investigator: TAMADA Tsutomu 川崎医科大学, 医学部, 准教授 (40278932)
• Co-Investigator(Kenkyū-buntansha): ITO Katsuyoshi 川崎医科大学, 医学部, 教授 (00274168) ; YAMASHITA Takenori 川崎医科大学, 医学部, 講師 (30299200)
• Co-Investigator(Renkei-kenkyūsha): SONE Teruki 川崎医科大学, 医学部, 教授 (90179383) ; JO Yoshimasa 川崎医科大学, 医学部, 講師 (40319968)
• Project Period (FY): 2009 – 2012
• Keywords: 前立腺癌 / 核磁気共鳴画像 / MRI

Research Abstract

In our studies using multiparametric prostate MR imaging, the tumor detectability of prostate cancer before radiotherapy (high-dose-rate brachytherapy (HDR-BT)), the change of MR findings after HDR-BT and the detectability of locally recurrent prostate cancer after HDR-BT were investigated. As the results, multiparametric MRI showed the high detectability for a significant cancer with the treatment intervention. In addition, after radiotherapy, the MR findings in T2-weighted imaging such as zonal indistinctness and diffuse reduction of the signal intensity in the gland interfered with the diagnosis of recurrent tumor. Furthermore, our results indicated that a multiparametric MRI protocol that includes diffusion-weighted imaging provides a sensitive method to detect local recurrence after HDR brachytherapy.

Research Products

• [Journal Article] Diffusion-weighted MRI and its role in prostate cancer (2013)
  • Author(s): Tamada T, Sone T, Jo Y, Yamamoto A, Ito K
  • Journal Title: NMR Biomed Volume: (印刷中)
  • DOI: doi:10.1002/nbm.2956.
  • Peer Reviewed
• [Journal Article] Prostate cancer detection in patients with total serum prostate-specific antigen levels of 4-10 ng/mL: diagnostic efficacy of diffusion-weighted imaging, dynamic contrast-enhanced MRI, and T2-weighted imaging. (2011)
  • Author(s): Tamada T, Sone T, Higashi H, Jo Y, Yamamoto A, Kanki A, Ito K.
  • Journal Title: AJR Am J Roentgenol. Volume: 197 Pages: 664-670
  • DOI: doi:10.2214/AJR.10.5923
  • Peer Reviewed
• [Journal Article] Locally recurrent prostate cancer after high-dose-rate brachytherapy: the value of diffusion-weighted imaging, dynamic contrast-enhanced MRI, and T2-weighted imaging in localizing tumors. (2011)
  • Author(s): Tamada T, Sone T, Jo Y, Hiratsuka J,Higaki A, Higashi H, Ito K
  • Journal Title: AJR Am J Roentgenol Volume: 197 Pages: 408-414
  • DOI: doi:10.2214/AJR.10.5772.
  • Peer Reviewed
• [Presentation] PROSTATE CANCER DETECTION IN PATIENTS WITH TOTAL SERUM PROSTATE-SPECIFIC ANTIGEN LEVELS BETWEEN 4 AND 10 NG/ML: DIAGNOSTIC EFFICACY OF MULTI-PARAMETRIC MR IMAGING (2012)
  • Author(s): Tsutomu Tamada, Hiroki Higashi,Teruki Sone, Yoshimasa Jo, Atsushi Higaki, Akihiko Kanki, Akira Yamamoto, and Katsuyoshi Ito.
  • Organizer: ISMRM
  • Place of Presentation: Melbourne オーストリア
  • Year and Date: 20120505-11
• [Presentation] 前立腺癌における高線量率組織内照射後の局所再発:MultiparametricMRIによる腫瘍検出能に関する検討 (2012)
  • Author(s): 玉田勉、常義政、曽根照喜、東浩樹、原稜英、永井敦、伊東克能.
  • Organizer: 日本泌尿器科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20120421-24
• [Presentation] Prostate cancer detection in patients with total serum prostate-specific antigen levels of4-10 ng/ml: diagnostic efficacy of diffusion-weighted imaging, dynamic contrast-enhanced MRI and T2-weighted imaging (2011)
  • Author(s): Tsutomu Tamada, Akira Yamamoto, Yoshimasa Jo, Hiroki Higashi, and Katsuyoshi Ito.
  • Organizer: ESUR-SUR
  • Place of Presentation: Dubrovnik クロアチア
  • Year and Date: 20111013-16
• [Presentation] MR Diagnosis in Prostate Cancer Detection: The Spectrum of Imaging Findings on Pre and Post Therapy (2010)
  • Author(s): Tsutomu Tamada, Katsuyoshi Ito, Hiroki Higashi, Daigo Tanimoto, Naoto Egashira, Fuyuki Tanaka, Tomohiro Sato, Akihiko Kanki, Atsushi Higaki, Teruyuki Torigoe, and Yasufumi Noda.
  • Organizer: RSNA
  • Place of Presentation: Chicago アメリカ
  • Year and Date: 20101128-1203
• [Presentation] Gray zone PSA症例の前立腺癌の検出におけるMRIの有用性 (2010)
  • Author(s): 玉田勉、常義政、曽根照喜、東浩樹、原稜英、永井敦、伊東克能.
  • Organizer: 日本泌尿器科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 20100421-24
• [Remarks] 川崎医科大学放射線医学(画像診断1)のHP,今回の研究結果の一部を掲載している。
  • URL: http://www.kawasaki-m.ac.jp/diag-radiology/