2011 Fiscal Year Final Research Report
Striatal serotonergic terminals in Parkinson's disease : a PET study
| Project/Area Number |
21591585
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Research institute for Brain and Blood Vesseis Akita |
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Principal Investigator |
MAEDA Tetsuya 秋田県立脳血管研究センター(研究局), 神経内科学研究部, 主任研究員 (70359496)
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| Research Collaborator |
KUDO Kazuhiko 秋田脳研, 放射線医学研究部, 研究員 (70462471)
YAMAGUCHI Hiroshi 秋田脳研, 放射線医学研究部, 研究員 (00450841)
IBARAKI Masanobu 秋田脳研, 放射線医学研究部, 研究員 (40360359)
NAKAMURA Kazuhiro 秋田脳研, 放射線医学研究部, 研究員 (10312638)
MATSUBARA Keisuke 秋田脳研, 放射線医学研究部, 研究員 (40588430)
KINOSHITA Toshifumi 秋田脳研, 放射線医学研究部, 部長 (70314599)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 核医学(PETを含む) |
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| Research Abstract |
Striatal serotonergic terminals play an important role in the onset of dopa-induced dyskinesia in Parkinson's disease(PD). Striatal serotonergic hyperinnervation(SSH) is familiar in the parkinsonian model rats, but not in PD patients. The aim of this study is to clarify the SSH in PD patients. We investigated glucose metabolism in patients with PD and completed the PET setting, while we could synthesize a serotonin transporter ligand and arrange the approval for use in PD patients.
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