2011 Fiscal Year Final Research Report
Development of new PET probe for tumor imaging using I-124
| Project/Area Number |
21591592
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
FUNAKI Yoshihito 東北大学, サイクロトロン・ラジオアイソトープセンター, 助教 (50261491)
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| Project Period (FY) |
2009 – 2011
|
| Keywords | ヨウ素124 / 腫瘍 / 小動物PET |
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| Research Abstract |
Labeled antibody and labeled modified antibody with I-124 were produced. Those labeled antibodies had specific bindings to cultured tumor cells. Labeled antibodies were not transported to the tumor in case of injection via tail vein but accumulated in urinary bladder. Moreover, it may be suggested that the hydrated electron that was high reductant produced in an aqueous solvent and the oxidized radioiodine was inhibited to generate.
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