Application of HIFU(High intensity focused ultrasound) to the treatment of liver cancer and evaluation of combined treatment of HIFU and RFA.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591596
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: SHIBATA Toshiya 京都大学, 医学研究科, 准教授 (60162632)
• Project Period (FY): 2009 – 2011
• Keywords: HIFU / RFA / 肝癌

Research Abstract

The coagulation area obtained by HIFU and RFA was compared in ex vivo and in vivo animal livers. In both ex vivo and in vivo studies, RFA has gained larger, homogeneous coagulation area with shorter treatment time than HIFU. A shortcoming of HIFU has been demonstrated to be longer treatment time and insufficient penetration. There might be some problems for the clinical application of HIFU to human liver cancer.

Research Products

• [Journal Article] Standard of hepatic vein reconstruction with patch plasty using native portal vein in adult living donor liver transplantation (2012)
  • Author(s): Mori A, Kaido T, Ogura Y, Ogawa K, Hata K, Yagi S, Yoshizawa A, Isoda H, Shibata T, Uemoto S.
  • Journal Title: Liver Transpl
  • DOI: DOI:10.1002/lt.23387
  • Peer Reviewed
• [Journal Article] Early evaluation of Tran catheter arterial chemoembolization-refractory hepatocellular carcinoma (2011)
  • Author(s): Yamanaka K, Hatano E, Kitamura K, Iida T, Ishii T, Machimito T, Taura K, Yasuchika K, Isoda H, Shibata T, Uemoto S.
  • Journal Title: J Gastroenterol
  • DOI: DOI:10.1007/s00535-011-0511-x
  • Peer Reviewed
• [Journal Article] Stent angioplasty for a kink in the pulmonary artery anastomosis soon after living-donor lobar lung transplantation. (2011)
  • Author(s): Chen F, Tazaki J, Shibata T, Miwa S, Yamazaki K, Ishii H, Shoji T, Fujinaga T, Bando T, Date H.
  • Journal Title: Ann Thorac Surg Volume: 92(5) Pages: 105-106
  • URL: http://dx.doi.org/10.1016/j.athoracsur.2011.05.049
  • Peer Reviewed
• [Journal Article] Contrast behavior of high-spatial-resolution T1-weighted MR imaging at 3. 0T vs. 1. 5T (2011)
  • Author(s): Isoda H, Arizono S, Shimada K, Hirokawa Y, Maetani YS, Kataoka M, Nakamoto Y, Shibata T, Togashi K.
  • Journal Title: Clin Imaging Volume: 35(2) Pages: 133-138
  • URL: http://dx.doi.org/10.1016/j.clinimag.2010.04.004
  • Peer Reviewed
• [Journal Article] Comparative study of cisplatin and epirubicin in Tran catheter arterial chemoembolization for hepatocellular carcinoma (2011)
  • Author(s): Yamanaka K, Hatano E, Narita M, Taura K, Yasuchika K, Nitta T, Arizono S, Isoda H, Shibata T, Ikai I, Sato T, Uemoto S.
  • Journal Title: Hepatol Res Volume: 41(4) Pages: 303-309
  • DOI: DOI:10.1111/j.1872-034X.2010.00770.x.
  • Peer Reviewed
• [Journal Article] Non-contrast-enhanced hepatic MR angiography : do two-dimensional parallel imaging and short tau inversion recovery methods shorten acquisition time without image quality deterioration (2011)
  • Author(s): Shimada K, Isoda H, Okada T, Kamae T, Arizono S, Hirokawa Y, Shibata T, and Togashi K.
  • Journal Title: European Journal of Radiology Volume: 77(1) Pages: 137-142
  • Peer Reviewed
• [Journal Article] FDG PET for giant cavernous hemangioma : important clue to differentiate from a malignant vascular tumor in the liver (2010)
  • Author(s): Shimada K, Nakamoto Y, Isoda H, Saito H, Arizono S, Shibata T, Togashi K.
  • Journal Title: Clin Nucl Med Volume: 35(12) Pages: 924-926
  • Peer Reviewed
• [Journal Article] Hepatic venous outflow obstruction in pediatric living donor liver transplantation using left-sided lobe grafts : Kyo University experience (2010)
  • Author(s): Sakamoto S, Egawa H, Kanazawa H, Shibata T, Miyagawa-Hayashino A, Haga H, Ogura Y, Kasahara M, Tanaka K, Uemoto S.
  • Journal Title: Liver Transpl Volume: 16(10) Pages: 1207-1214
  • Peer Reviewed
• [Journal Article] Comparison of gadolinium-EOB-DTPA-enhanced and diffusion-weighted liver MRI for detection of small hepatic metastases (2010)
  • Author(s): Shimada K, Isoda H, Hirokawa Y, Arizono S, Shibata T, Togashi K.
  • Journal Title: Eur Radiol Volume: 20(11) Pages: 2690-2698
  • Peer Reviewed
• [Journal Article] Improved Detection of Hepatic Metastases From Pancreatic Cancer Using Periodically Rotated Overlapping Parallel Lines With Enhanced Reconstruction(PROPELLER) Technique After SPIO Administration (2010)
  • Author(s): Hirokawa Y, Isoda H, Okada T, Arizono S, Shimada K, Yamamoto A, Shibata T, Togashi K.
  • Journal Title: Invest Radiol Volume: 45(3) Pages: 158-164
  • Peer Reviewed
• [Journal Article] Balloon-occluded retrograde Tran venous obliteration for duodenal varices complicated by intraprocedural rupture followed by sepsis (2010)
  • Author(s): Akasaka T, Shibata T, Isoda H, Arizono S, Shimada K, Taura K, Togashi K.
  • Journal Title: Cardiovasc Intervent Radiol Volume: 33(6) Pages: 1257-1261
  • Peer Reviewed
• [Journal Article] High spatial resolution 3D MR cholangiography with high sampling efficiency technique(SPACE): Comparison of 3. 0Tvs1. 5T (2010)
  • Author(s): Nakamoto Y, Shibata T, Togashi K.
  • Journal Title: Eur J Radiol Volume: 73(1) Pages: 114-118
  • Peer Reviewed
• [Presentation] Radiofrequency ablation guided by contrast harmonic sonography using perfluorocarbon microbubbles(Sonazoid) for small hepatocellular carcinoma (2011)
  • Author(s): Shibata T, Yabuta M, Shibata T, Isoda H, Togashi K.
  • Organizer: the 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America
  • Place of Presentation: Chicago
  • Year and Date: 2011-11-27
• [Presentation] Multichannel radiofrequency excitation upper abdominal MR imaging at 3T : challenges and their solutions (2011)
  • Author(s): Shimizu H, Isoda H, Kawahara S, Shimada T, Shibata T, Togashi K.
  • Organizer: the 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America
  • Place of Presentation: Chicago
  • Year and Date: 2011-11-27
• [Presentation] Radiofrequency ablation guided by contrast harmonic sonography using perfluorocarbon microbubbles(Sonazoid) for small hepatocellular carcinoma (2011)
  • Author(s): Shibata T, Shibata T, Yabuta M, Isoda H, Togashi K.
  • Organizer: Electronic Posters
  • Place of Presentation: Munich
  • Year and Date: 2011-09-10
• [Presentation] IVR達人への道(1) S-12小肝細胞癌に対するソナゾイド造影USガイドRFAの有用性 (2011)
  • Author(s): 柴田登志也、芝田豊通、薮田実、磯田裕義、富樫かおり
  • Organizer: 第40回日本IVR学会総会
  • Place of Presentation: 於青森市文化会館
  • Year and Date: 2011-05-19
• [Presentation] Long-term results of percutaneous transluminal angioplasty for anastomotic stenosis of hepatic vein after living donor liver transplantation (2010)
  • Author(s): Shibata T, Isoda H, Shimada K, Togashi K.
  • Organizer: the 96th Scientific Assembly and Annual Meeting of the Radiological Society of North America
  • Place of Presentation: Chicago
  • Year and Date: 2010-12-01
• [Presentation] Percutaneous transhepatic angioplasty for anastomotic stenosis of portal vein in patients with living donor liver transplantation : long-term results (2010)
  • Author(s): Shibata T, Isoda H, Togashi K.
  • Organizer: FP1204-TIPS and portal vein intervention
  • Place of Presentation: Valencia
  • Year and Date: 2010-10-03
• [Presentation] Long-term results of percutaneous transluminal angioplasty for anastomotic stenosis of hepatic vein after living donor liver transplantation (2010)
  • Author(s): Yabuta M, Shibata T, Shibata T, Isoda H, Togashi K.
  • Organizer: Electronic Posters
  • Place of Presentation: Munich
  • Year and Date: 2010-09-10
• [Presentation] 肝移植後合併症に対するIVRS-29生体肝移植後肝静脈狭窄に対するIVR (2010)
  • Author(s): 柴田登志也、磯田裕義、富樫かおり
  • Organizer: 第39回日本IVR学会総会
  • Place of Presentation: 於浅草ビューホテル
  • Year and Date: 2010-05-21