Development of optimal radiotherapy schedule on concurrent chemoradiotherapy for locally advanced uterine cervical cancer

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591614
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of the Ryukyus
• Principal Investigator: TOITA Takafumi 琉球大学, 医学研究科, 准教授 (30237036)
• Co-Investigator(Kenkyū-buntansha): NAGAI Yutaka 琉球大学, 医学部附属病院, 講師 (70305209) ; KAKINOHANA Yasumasa 琉球大学, 医学研究科, 助教 (20185713) ; FUJIWARA Keiichi 埼玉医科大学, 医学部, 教授 (20238629) ; TESHIMA Teruki 大阪大学, 医学(系)研究科, 教授 (40136049) ; ISHIKURA Satoshi 名古屋市立大学, 医学部, 准教授 (40407242) ; UNO Takashi 千葉大学, 医学(系)研究科, 准教授 (30302540)
• Project Period (FY): 2009 – 2011
• Keywords: 子宮頸癌 / 放射線治療 / 同時化学放射線療法 / 臨床試験 / 品質保証

Research Abstract

In concurrent chemoradiotherapy for patients with locally advanced cervical cancer, lower total radiation dose has been utilized in Japan compared with global dose recommended by the US investigators. To determine whether the Japanese radiation dose is appropriate, multi-institutional prospective study(JGOG1066) was conducted. The study demonstrated both safety and efficacy of the Japanese radiotherapy dose.

Research Products

• [Journal Article] Prospective multi-institutional study of definitive radiotherapy with high-dose-rate intracavitary brachytherapy in patients with nonbulky(<4-cm) stage I and II uterine cervical cancer(JAROG0401/JROSG04-2) (2012)
  • Author(s): Toita T, Kato S, Niibe Y, Ohno T, Kazumoto T, Kodaira T, Kataoka M, Shikama N, Kenjo M, Tokumaru S, Yamauchi C, Suzuki O, Sakurai H, Numasaki H, Teshima T, Oguchi M, Kagami Y, Nakano T, Hiraoka M, Mitsuhashi N
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 82 Pages: e49-56
  • Peer Reviewed
• [Journal Article] International Brachytherapy Practice Patterns : A Survey of the Gynecologic Cancer Intergroup(GCIG) (2012)
  • Author(s): Viswanathan AN, Creutzberg CL, Craighead P, McCormack M, Toita T, Narayan K, Reed N, Long H, Kim HJ, Marth C, Lindegaard JC, Cerrotta A, Small W Jr, Trimble E
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 82(1) Pages: 250-5
  • Peer Reviewed
• [Journal Article] Disease Committee of Radiation Oncology, Japanese Gynecologic Oncology Group. Radiotherapy quality assurance of the Japanese Gynecologic Oncology Group study(JGOG1066): a cooperative phase II study of concurrent chemoradiotherapy for uterine cervical cancer (2011)
  • Author(s): Toita T, Kato S, Ishikura S, Tsujino K, Kodaira T, Uno T, Hatano K, Sakurai H, Niibe Y, Kazumoto T, Nishimura T, Kitagawa R, Fukutani M, Oguchi M, Umayahara K, Hirashima Y, Aoki Y, Takizawa K
  • Journal Title: Int J Clin Oncol Volume: 16 Pages: 379-86
  • Peer Reviewed
• [Journal Article] JCOG Radiation Therapy Study Group. A consensus-based guideline defining clinical target volume for primary disease in external beam radiotherapy for intact uterine cervical cancer (2011)
  • Author(s): Toita T, Ohno T, Kaneyasu Y, Kato T, Uno T, Hatano K, Norihisa Y, Kasamatsu T, Kodaira T, Yoshimura R, Ishikura S, Hiraoka M
  • Journal Title: Jpn J Clin Oncol Volume: 41(9) Pages: 1119-26
  • Peer Reviewed
• [Journal Article] A consensus-based guideline defining the clinical target volume for pelvic lymph nodes in external beam radiotherapy for uterine cervical cancer (2010)
  • Author(s): Toita T, Ohno T, Kaneyasu Y, Uno T, Yoshimura R, Kodaira T, Furutani K, Kasuya G, Ishikura S, Kamura T, Hiraoka M
  • Journal Title: Jpn J Clin Oncol Volume: 40 Pages: 456-63
  • Peer Reviewed
• [Journal Article] がん臨床試験と放射線療法:放射線治療の品質保証(QA)・品質管理(QC)の重要性.特集:婦人科がん臨床試験参加に必要な知識 (2010)
  • Author(s): 戸板孝文、石倉聡、村山貞之
  • Journal Title: 産科と婦人科 Volume: 77 Pages: 542-546
• [Journal Article] Quality assurance in the prospective multi-institutional trial on definitive radiotherapy using high-dose-rate intracavitary brachytherapy for uterine cervical cancer : the individual case review (2009)
  • Author(s): Toita T, Oguchi M, Ohno T, Kato S, Niibe Y, Kodaira T, Kazumoto T, Kataoka M, Shikama N, Kenjo M, Teshima T, Kagami Y
  • Journal Title: Jpn J Clin Oncol Volume: 39 Pages: 813-9
  • Peer Reviewed
• [Journal Article] Patterns of care for radiotherapy in vulvar cancer : a Gynecologic Cancer Intergroup study (2009)
  • Author(s): Gaffney DK, Du Bois A, Narayan K, Reed N, Toita T, Pignata S, Blake P, Portelance L, Sadoyze A, Potter R, Colombo A, Randall M, Mirza MR, Trimble EL
  • Journal Title: Int J Gynecol Cancer Volume: 19 Pages: 163-7
  • Peer Reviewed
• [Journal Article] Current status and perspectives of brachytherapy for cervical cancer (2009)
  • Author(s): Toita T
  • Journal Title: Int J Clin Oncol Volume: 14 Pages: 25-30
• [Journal Article] Cervical Cancer(Vulva Cancer) Committee of the Japanese Gynecologic Oncology Group(JGOG). Phase II study of concurrent chemoradiotherapy with high-dose-rate intracavitary brachytherapy in patients with locally advanced uterine cervical cancer : Efficacy a
  • Author(s): Toita T, Kitagawa R, Hamano T, Umayahara K, Hirashima Y, Aoki Y, Oguchi M, Mikami M, Takizawa K
  • Journal Title: Gynecol Oncol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Insufficiency Fractures After Pelvic Radiation Therapy for Uterine Cervical Cancer : An Analysis of Subjects in a Prospective Multi-institutional Trial, and Cooperative Study of the Japan Radiation Oncology Group(JAROG) and Japanese Radiation Oncology Study Group(JROSG)
  • Author(s): Tokumaru S, Toita T, Oguchi M, Ohno T, Kato S, Niibe Y, Kazumoto T, Kodaira T, Kataoka M, Shikama N, Kenjo M, Yamauchi C, Suzuki O, Sakurai H, Teshima T, Kagami Y, Nakano T, Hiraoka M, Mitsuhashi N, Kudo S
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: (In press)
  • Peer Reviewed
• [Presentation] Phase II study of concurrent chemoradiotherapy with hig-dose-rate intracavitary brachytherapy of low cumulative prescribed dose schedule for locally advanced cervical carcinoma in Japanese women(JGOG1066) (2012)
  • Author(s): Umayahara K, Toita T, et al
  • Organizer: The 2012 Annual Meeting on Women's Cancer
  • Place of Presentation: Austin
  • Year and Date: 2012-03-24
• [Presentation] Prospective multi-institutional study of definitive radiotherapy with high-dose rate intracavitary brachytherapy in patients with non-bulky(<4cm) stage I, II uterine cervical cancer(JAROG0401/JROSG04-2) (2010)
  • Author(s): Toita T, et al
  • Organizer: 52^<nd> Annual Meeting of ASTRO
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-03
• [Book] 婦人科腫瘍子宮頸癌 (2010)
  • Author(s): 戸板孝文
  • Total Pages: 997-1004
  • Publisher: 篠原出版新社