2011 Fiscal Year Final Research Report
Enhancement of hypoxic cell killing and gene therapy applications to cancer treatment
| Project/Area Number |
21591618
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
KAGIYA Go 北里大学, 医療衛生学部, 講師 (30524243)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OGAWA Ryohei 富山大学, 大学院・医学薬学研究部, 講師 (60334736)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO Hideki 福井大学, 高エネルギー医学研究センター, 准教授 (40142377)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 低酸素細胞領域 / ニトロキシド化合物 / 殺細胞効果 |
|---|
| Research Abstract |
We have found that tempol, one of nitoxides, strongly induced the expression of hypoxia inducible-factor(HIF) 1alpha with a combination of hypoxic conditions. The aim of this study is to construct the plasmids that regulate the expression of suicide gene with tempol and to evaluate the enhancement of the cell killing effect by tempol. The transfected cells with the plasmid encoding suicide gene indicated the highest cell killing effect after treatment of 5-FC, tempol and hypoxic mimic CoCl_2.
|
Research Products
(11 results)
-
-
[Journal Article] Regulation of gene expression in retrovirus vectors by X-ray and proton beam radiation with artificially constructed promoters2012
Author(s)
Ogawa, R., A. Morii, A. Watanabe, Z. G. Cui, G. Kagiya, S. Fukuda, K. Kume, T. Hasegawa, M. Hatashita, H. Izumi and T. Ishimoto
-
Journal Title
J Gene Med
Volume: 14
Pages: 316-327
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
[Presentation] 診療放射線技師教育における学術国際交流2009
Author(s)
佐藤英介, 鍵谷豪, 稲田龍司, 梅田徳男, 小川幸次, 五味勉, 斉藤京子, 長谷川智之, 原秀剛, 村石浩, 尾崎正則, 武田徹, 丸山浩一
Organizer
第3回日本診療放射線学教育学会大会
Place of Presentation
相模原市
Year and Date
2009-08-01
-
