2011 Fiscal Year Final Research Report
A prophylaxis and a treatment for radiation induced mucosal damage-Efficacy of zinc to radiation proctitis using an animal experimental model-
| Project/Area Number |
21591622
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Masayuki 兵庫医科大学, 医学部, 助教 (90388827)
TAKADA Yasuhiro 兵庫医科大学, 医学部, 助教 (20461048)
HIROTA Shozo 兵庫医科大学, 医学部, 教授 (20181216)
MAEDA Hiroaki 兵庫医科大学, 医学部, 助教 (00388828)
KOBAYASHI Kaoru 兵庫医科大学, 医学部, 助教 (70388817)
YAMAMOTO Satoshi 兵庫医科大学, 医学部, 助教 (50411989)
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| Co-Investigator(Renkei-kenkyūsha) |
DOI Hiroshi 兵庫医科大学, 医学部, 助教 (50529047)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 放射線治療学 / 放射線障害 |
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| Research Abstract |
Fifty-four female Wistar rats were used. All rats were irradiated with a single fraction of 25 Gy without any invasive procedures under pentobarbital anesthesia. Polaprezinc was prepared as ointment. Ointment was administrated rectally without any anesthesia each day after irradiation. All animals were sacrificed on the tenth day following irradiation. Colonoscopy was performed to evaluate the macroscopic findings immediately after sacrifice. The rectum was excised for a pathological evaluation following colonoscopy. The pathological evaluation assessed the morphological mucosal damage, the degree of inflammation, and the depth of inflammation. The results were graded from 0 to 4, and compared according to milder or more severe status as applicable. The PZ(+) group tended to show milder mucosal damage than the other groups in all criteria. In addition, significant differences were observed between the PZ(+) group and the Control group in the endoscopic findings, the degree of inflammation and the depth of inflammation. This model was confirmed to be a useful experimental rat model for radiation proctitis. The present study demonstrated the efficacy of Polaprezinc against acute radiation-induced rectaldisorders using the rat model.
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