2011 Fiscal Year Final Research Report
To elucidate the immune activity of heavy ion irradiation in inhibiting lung metastasis in treatment-resistant cancer
| Project/Area Number |
21591624
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
YAMADA Shigeru 独立行政法人放射線医学総合研究所, 重粒子医科学センター病院, 室長 (80311380)
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| Research Collaborator |
SHINOTO Makoto 独立行政法人放射線医学総合研究所, 重粒子医科学センター病院, 治療室医員 (50551503)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 重粒子 / 転移 / 難治性がん |
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| Research Abstract |
The cell mediated immunity mainly on the NK-cell was activated by heavy-ion particle radiation, and the suppression of metastases was induced by the activation. Heavy-ion particle radiation induced monitoring cells such as a macrophage, dendritic cells or the mast cells which had TLR(Toll like receptor) to recognize cancer cells easily, and an NK-cell was activated by increasing a production of TNF-α and IL-12 which were cytokines secreted by those cells more or IL-12 and increased a production of IFN - γ secreted more by an NK-cell, and it was shown that various cell mediated immunity mechanisms were activated, and the antitumor action for metastases was demonstrated.
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[Presentation] Pancreas / Rectum2012
Author(s)
Shigeru Yamada, Makoto Shinoto, Koutaro Terashima, Shigeo Yasuda, Hiroshi Imada, Tadashi Kamada, Hirohiko Tsujii, Shinichiro Mori
Organizer
51st Annual Meeting of Particle Therapy Co-Operrative Group
Place of Presentation
ソウル
Year and Date
20120514-16
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[Presentation] Pancreas Cancer2010
Author(s)
Shigeru Yamada, Makoto Shinoto, Hiroshi Imada
Organizer
II NIRS-CNAO Joint Symposium on Hadrontherapy
Place of Presentation
ミラノ
Year and Date
20100320-21
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