2011 Fiscal Year Final Research Report
Development of small-diameter vascular graft composed of antithrombogenic phospholipid polymer
| Project/Area Number |
21591628
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOYAMA Hiroyuki 東京大学, 医学部附属病院, 特任准教授 (10241994)
MIYATA Tetsurou 東京大学, 医学部附属病院, 准教授 (70190791)
SHIGEMATSU Kunihiro 東京大学, 医学部附属病院, 講師 (20215966)
KIMURA Hideo 東京大学, 医学部附属病院, 助教 (60327070)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 小口径人工血管 / MPCポリマー / 抗血栓性 |
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| Research Abstract |
The patency rates of carotid or femoral arterial bypass with MPC-coated and noncoated ePTFE grafts were 9/37(24%) and 14/37(38%) after one week ; 4/37(11%) and 6/37(15%) after two weeks ; and 3/37(8%) and 3/37(8%) after four weeks. Based on a histological examination, the thrombus was attached to the cut edges of the host artery. Intimal hyperplasia at the anastomosis and the surface of MPC-coated grafts was not changed remarkably compared with noncoated grafts.
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