Genetic polymorphism of TLR CD40L in the mechanism of pathogenesis of Buerger's disease

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591630
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KUDO Toshifumi 東京医科歯科大学, 医学部・附属病院, 助教 (50431911)
• Co-Investigator(Kenkyū-buntansha): INOUE Yoshinori 東京医科歯科大学, 医歯(薬)学総合研究科, 講師 (70280964) ; JIBIKI Masatoshi 東京医科歯科大学, 医学部附属病院, 助教 (50422481)
• Project Period (FY): 2009 – 2011
• Keywords: 血管外科学 / Buerger病 / TLR / 歯周病 / 遺伝的多型

Research Abstract

Myeloid differentiation primary-response protein 88(MyD88) is a key signaling adaptor for all Toll-like receptors. The frequency of GG genotype was significantly lower in the Buerger's disease patients than in the controls. The frequency of Formyl peptide receptors(FPR) 1 TCCCT haplotype was significantly higher in the Buerger's Disease patients than in the controls. The results of the current study suggest that TLR-MyD88 pathway and bacterial infection immunity play a role in the mechanism of pathogenesis of Buerger's disease as well as periodontal disease.

Research Products

• [Journal Article] A single nucleotide polymorphism in the 3'-untranslated region of MyD88 gene is associated with Buerger disease but not with Takayasu arteritis inJ apanese (2011)
  • Author(s): Chen Z, Nakajima T, Inoue Y, Kudo T, Jibiki M, Iwai T, Kimura A
  • Journal Title: J Hum Genet Volume: 56 Pages: 545-547
• [Journal Article] Whole-blood platelet aggregation by porphyromonas gingivalis in patients with peripheral arterial disease (2011)
  • Author(s): Notani H, Inoue Y, Sugano N, Jibiki M, Umeda M, Izumi Y
  • Journal Title: J Med Dent Sci Volume: 58 Pages: 7-14
• [Journal Article] The periodontal anaerobe porphyromonas gingivalis induced platelet activation and increased aggregation in whole blood by rat model (2011)
  • Author(s): Kangmin Y, Inoue Y, Umeda M, Terasaki H, Chen Z, Iwai T
  • Journal Title: Thromb Res Volume: 127 Pages: 418-425
• [Journal Article] Differential detection rate of periodontopathic bacteria in atherosclerosis (2011)
  • Author(s): Toyofuku T, Inoue Y, Kurihara N, Kudo T, Jibiki M, Sugano N, Umeda M, Izumi Y.
  • Journal Title: Surg Today Volume: 41 Pages: 1395-1400
• [Journal Article] バージャー病患者の逍遥性静脈炎、表在静脈弁不全についての考察と新知見 (2011)
  • Author(s): 岩井武尚, 佐藤彰治, 久米博子, 井上芳〓, 梅田誠, 加賀山知子, 広川雅之
  • Journal Title: 静脈学 Volume: 22 Pages: 25-31
• [Journal Article] 血管疾患と歯周病 (2010)
  • Author(s): 井上芳〓
  • Journal Title: Angiology Frontier Volume: 9 Pages: 160-165
• [Journal Article] Buerger disease : new evidence. Davies AH, Mitchell AWM Edited (2009)
  • Author(s): Iwai T, Inoue Y, Li X, Umeda M
  • Journal Title: Vasc Endovasc Surg Highlights Volume: 2008-09 Pages: 93-98
• [Journal Article] Association between periodontitis and anti-cardiolipin antibodies in Buerger disease (2009)
  • Author(s): Chen YW, Nagasawa T, Wara-aswapati N, Ushida Y, Wang D, Takeuchi Y, Kobayashi H, Umeda M, Inoue Y, Iwai I, Ishikawa I, Izumi Y.
  • Journal Title: J Clin Periodontol Volume: 10 Pages: 830-835
• [Journal Article] 閉塞性動脈硬化症でのPorphyromonas gingivalisによる全血凝集反応の意義について (2009)
  • Author(s): 地引政利、野谷啓之、井上芳〓
  • Journal Title: 脈管学 Volume: 49 Pages: S162
• [Journal Article] 歯周病と動脈硬化 (2009)
  • Author(s): 井上芳〓
  • Journal Title: 成人病と生活習慣病 Volume: 39 Pages: 514-518
• [Presentation] Free paper session : Basic research/Varia TK4. 4-2 Clinical study of Phlebitis Migrans and incompetence of the leg superficial vein in Buerger Disease (2011)
  • Author(s): Iwai T, Sato S, Kume H, Inoue Y, Umeda M, Kagayama T.
  • Organizer: International Congress of the Union Internationale de Phlebologic European Chapter Meeting
  • Place of Presentation: Prague
  • Year and Date: 20110915-17
• [Presentation] The evolution of the research on Buerger Disease (2011)
  • Author(s): Iwai T, Inoue Y, Umeda M, Li X, Chen Z, Nakamura H, Kurihara N, Nuttawud S, Chen Y-W
  • Organizer: Buerger Disease Forum in Chiang Mai 2011. Oral presentation
  • Place of Presentation: Chiang Mai
  • Year and Date: 20110617-19
• [Presentation] Synergistic contribution of CD14 and HLA Loci in the susceptibility to Buerger Disease (2011)
  • Author(s): Koizumi S. Chen Z, Takahashi M, Naruse T, Nakajima T, Chen Y-W, Inoue Y, Ishikawa I, Iwai T, Kume H
  • Organizer: Buerger Disease Forum in Chiang Mai 2011. Oral presentation
  • Place of Presentation: Chiang Mai
  • Year and Date: 20110617-19
• [Presentation] Differential diagnosis of Buerger disease (2011)
  • Author(s): Igari K, Yonekura K, Uchiyama H, Koizumi S, Toyofuku T, Kudo T, Jibiki M, Sugano N, Inoue Y, Iwai T.
  • Organizer: Buerger Disease Forum in Chiang Mai 2011. Oral presentation
  • Place of Presentation: Chiang Mai
  • Year and Date: 20110617-19
• [Presentation] Clinical study of phlebitis migrans and incompetence of the leg superficial vein in Buerger Disease (2011)
  • Author(s): Iwai T, Sato S, Kume H, Inoue Y, Umeda M, Kagayama T.
  • Organizer: Buerger Disease Forum in Chiang Mai 2011. Oral presentation
  • Place of Presentation: Chiang Mai
  • Year and Date: 20110617-19
• [Presentation] Enhanced adhesion of early endothelial progenitor cells to radiation-induced senescence-like vascular endothelial cells in vitro (2011)
  • Author(s): Nuttawut S, Ishii H, Igarashi K, Miura M, Yoshida M, Inoue Y, Iwai T.
  • Organizer: Buerger Disease Forum in Chiang Mai 2011. Oral presentation
  • Place of Presentation: Chiang Mai
  • Year and Date: 20110617-19
• [Presentation] Periodontitis and Vascular diseases, the concern ofperiodontal pathogens (2011)
  • Author(s): Umeda M, G. Amodini R, Iwai T, Inoue Y, Izumi Y.
  • Organizer: Buerger Disease Forum in Chiang Mai 2011. Oral presentation
  • Place of Presentation: Chiang Mai
  • Year and Date: 20110617-19
• [Presentation] Porphyromonas gingivalis make platelet aggregate in whole blood (2010)
  • Author(s): Koizumi S, Kudo T, Jibiki M, Sugano N, Inoue Y.
  • Organizer: The 11th Annual Congress of Asian Society for Vascular Surgery
  • Place of Presentation: Oral presentation. Kyoto
  • Year and Date: 20100629-0702
• [Presentation] 閉塞性動脈硬化症でのPorphyromonas gingivalisによる全血凝集反応の意義について (2009)
  • Author(s): 地引政利,野谷啓之,工藤敏文,菅野範英,井上芳〓
  • Organizer: 第50回日本脈管学会
  • Place of Presentation: 東京
  • Year and Date: 20091029-31
• [Presentation] 閉塞性動脈硬化症に対する、歯周病原細菌の関連 (2009)
  • Author(s): 豊福崇浩,井上芳〓,寺崎宏明,工藤敏文,地引政利,菅野範英,梅田誠,和泉雄三,須田智也,岩井武尚
  • Organizer: 第109回日本外科学会
  • Place of Presentation: 福岡
  • Year and Date: 20090402-0404