2011 Fiscal Year Final Research Report
Basic study for establishment for personalized immunosuppressive therapy for organ transplantation
| Project/Area Number |
21591653
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Department of Clinical Research, National Hospital Organization Mito Medical Center |
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Principal Investigator |
YUZAWA Kenji 独立行政法人国立病院機構水戸医療センター(臨床研究部), 移植医療研究室, 室長 (10240160)
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| Co-Investigator(Kenkyū-buntansha) |
HOMMA Masato 筑波大学, 人間総合科学研究科臨床薬理学, 准教授 (90199589)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 移植外科学 |
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| Research Abstract |
Now, immunosuppressive therapies for organ transplanted patients are uniform. This study was performed to establish the personalized immunosuppressive therapy for the patients. We evaluated the relationship among blood concentration of the drugs, drug dosage, gene polymorphism of drug metabolism, immunosuppressive status measured by ImmuKnow, period after transplantation and age. We could not obtain significant relationship among these factors. It seemed to be necessary to evaluate more patients, more polymorphism, more accurate measurement of immunosuppressive status.
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Research Products
(12 results)
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[Journal Article] Difference in blood tacrolimusconcentration between ACMIA and MEIAin samples with low haematocrit values2010
Author(s)
Doki K, Homma M, Hori T, Tomita T, Hasegawa Y, Ito S, Fukunaga K, Kaneko M, Chiba S, Sumida T, Ohkohchi N, Kohda Y.
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Journal Title
J Pharm Pharmacol
Volume: Vol62, No9
Pages: 1185-1188
Peer Reviewed
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