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2011 Fiscal Year Final Research Report

Mechanism of premetastatic niche formation and promotion of metastasis by cancer mesenchymal cells

Research Project

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Project/Area Number 21591655
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionHokkaido University

Principal Investigator

HIDA Yasuhiro  北海道大学, 北海道大学病院, 講師 (30399919)

Co-Investigator(Kenkyū-buntansha) HIDA Kyoko  北海道大学, 大学院・歯学研究科, 特任准教授 (40399952)
KONDO Satoshi  北海道大学, 大学院・医学研究科, 教授 (30215454)
Project Period (FY) 2009 – 2011
Keywords癌 / 転移 / 血管新生 / 血管内皮細胞 / ニッシェ
Research Abstract

Promotion of lung metastasis by interaction between tumor and tumor endothelial cells
In this study, it was shown that tumor endothelial cells promote invasion and metastasis of tumor cells using cells labeled with fluorescein proteins. Tumor cells inoculated to mice with tumor endothelial cells circulated in peripheral blood and metastasized to lungs more than control conditions. The mechanism are enhanced migration of tumor cells towards tumor endothelial cells and transendothelial migration.

  • Research Products

    (22 results)

All 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (7 results) Book (1 results) Remarks (1 results)

  • [Journal Article] CXCR7: A novel tumor endothelial marker in renal cell carcinoma2012

    • Author(s)
      Maishi N, Ohga N, Hida Y, Akiyama K, Shinohara N, Nonomura K, Shindoh M, Hida K. Kitayama K, Osawa T, Onodera Y
    • Journal Title

      Pathol Int

      Volume: 65(5) Pages: 309-17

    • DOI

      DOI:10.1111/j.1440-1827.2012.02792.x

    • Peer Reviewed
  • [Journal Article] Tumor-Derived Microvesicles Induce Proangiogenic Phenotype in Endothelial Cells via Endocytosis2012

    • Author(s)
      Kawamoto T, Ohga N, Akiyama K, Hirata N, Kitahara S, Maishi N, Osawa T, Yamamoto K, Kondoh M, Shindoh M, Hida Y, Hida K.
    • Journal Title

      PLoS One

      Volume: 7(3) Pages: e34045

    • Peer Reviewed
  • [Journal Article] Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner2012

    • Author(s)
      Osawa T, Ohga N, Hida Y, Kitayama K, Akiyama K, Onodera Y, Fujie M, Shinohara N, Shindoh M, Nonomura K, Hida K
    • Journal Title

      Cancer Sci

    • DOI

      DOI:10.1111/j.1349-7006.2012.02261.x

    • Peer Reviewed
  • [Journal Article] Biglycan is a aspecific marker and an autocrine angiogenic factor of tumour endothelial cells2012

    • Author(s)
      Yamamoto K, Ohga N, Hida Y, Maishi N, Kawamoto T, Kitayama K, Akiyama K, Osawa T, Kondoh M, Matsuda K, Onodera Y, Fujie M, Kaga K, Hirano S, Shinohara N, Shindoh M, Hida K.
    • Journal Title

      Br J Cancer

      Volume: 106(6) Pages: 1214-23

    • DOI

      DOI:10.1038/bjc.2012.59

    • Peer Reviewed
  • [Journal Article] Differential expressions of matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs and their endogenous inhibitors among histologic subtypes of lung cancers2012

    • Author(s)
      Hida Y, Hamada JI.
    • Journal Title

      Anticancer Agents Med Chem

    • Peer Reviewed
  • [Journal Article] Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment2012

    • Author(s)
      Akiyama K, Ohga N, Hida Y, Kawamoto T, Sadamoto Y, Ishikawa S, Maishi N, Akino T, Kondoh M, Matsuda A, Inoue N, Shindoh M, Hida K.
    • Journal Title

      Am J Pathol

      Volume: 180(3) Pages: 1283-93

    • Peer Reviewed
  • [Journal Article] Heterogeneity of tumor endothelial cells : comparison between tumor endothelial cells isolated from high-and low-metastatic tumors2012

    • Author(s)
      Ohga N, Ishikawa S, Maishi N, Akiyama K, Hida Y, Kawamoto T, Sadamoto Y, Osawa T, Yamamoto K, Kondoh M, Ohmura H, Shinohara N, Nonomura K, Shindoh M, Hida K.
    • Journal Title

      Am J Pathol

      Volume: 180(3) Pages: 1297-307

    • Peer Reviewed
  • [Journal Article] Cyclooxygenase-2 inhibition causes antiangiogenic effects on tumor endothelial and vascular progenitor cells2012

    • Author(s)
      Muraki C, Ohga N, Hida Y, Nishihara H, Kato Y, Tsuchiya K, Matsuda K, Totsuka Y, Shindoh M, Hida K.
    • Journal Title

      Int J Cancer

      Volume: 130(1) Pages: 59-70

    • DOI

      DOI:10.1002/ijc.25976

    • Peer Reviewed
  • [Journal Article] Altered angiogenesis in the tumor microenvironment2011

    • Author(s)
      Hida K, Kawamoto T, Ohga N, Akiyama K, Hida Y, Shindoh M.
    • Journal Title

      Pathol Int

      Volume: 61(11) Pages: 630-7

    • DOI

      DOI:10.1111/j.1440-1827.2011.02726.x

    • Peer Reviewed
  • [Journal Article] Imatinib mesylate inhibits the proliferation-stimulating effect of human lung cancer-associated stromal fibroblasts on lung cancer cells2010

    • Author(s)
      Kinoshita K, Nakagawa K, Hamada J, Hida Y, Tada M, Kondo S, Moriuchi T.
    • Journal Title

      Int J Oncol

      Volume: 37(4) Pages: 869-77

    • Peer Reviewed
  • [Journal Article] Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization2010

    • Author(s)
      Tsuchiya K, Hida K, Hida Y, Muraki C, Ohga N, Akino T, Kondo T, Miseki T, Nakagawa K, Shindoh M, Harabayashi T, Shinohara N, Nonomura K, Kobayashi M.
    • Journal Title

      Int J Oncol

      Volume: 36(6) Pages: 1379-86

    • Peer Reviewed
  • [Journal Article] Isolation and culture of microvascular endothelial cells from murine inguinal and epididymal adipose tissues2010

    • Author(s)
      Kajimoto K, Hossen MN, Hida K, Ohga N, Akita H, Hyodo M, Hida Y, Harashima H.
    • Journal Title

      J Immunol Methods

      Volume: 357(1-2) Pages: 43-50

    • Peer Reviewed
  • [Journal Article] Isolated tumor endothelial cells maintain specific character during long-term culture2010

    • Author(s)
      Matsuda K, Ohga N, Hida Y, Muraki C, Tsuchiya K, Kurosu T, Akino T, Shih SC, Totsuka Y, Klagsbrun M, Shindoh M, Hida K.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 394(4) Pages: 947-54

    • Peer Reviewed
  • [Presentation] Biglycan is a specific marker and an autocrine angiogenic factor of tumor endothelial cells2012

    • Author(s)
      Yamamoto K., Ohga N., Hida Y., Maishi N., Kawamoto T., Kitayama K., Akiyama K., Osawa T., Kondoh M., Kaga K., Hirano S., Shinohara N., Shindoh M., Hida K.
    • Organizer
      AACR ANNUAL MEETING 2012
    • Place of Presentation
      Chicago, Illinois
    • Year and Date
      2012-04-02
  • [Presentation] Analysis of interaction between tumor endothelial cells and tumor cells2011

    • Author(s)
      Maishi N., Ohga N., Hida Y., Ohba Y., Kawamoto T., Akiyama K., Kitayama K., Kondoh M., Ohsawa T., Yamamoto K., Inoue N., Shindoh M., Hida K.
    • Organizer
      AACR 102^<nd> ANNUAL MEETING 2011
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      20110402-06
  • [Presentation] 腫瘍血管内皮細胞とがん転移との相互作用解析2011

    • Author(s)
      間石奈湖、大賀則孝、樋田泰浩、大場雄介、浜田淳一、秋山廣輔、山本和幸、大澤崇宏、近藤美弥子、川本泰輔、進藤正信、井上農夫男、樋田京子
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2011-10-05
  • [Presentation] 腫瘍血管内皮におけるBiglycanの機能解析2011

    • Author(s)
      山本和幸、大賀則孝、樋田泰浩、北山和子、間石奈湖、大澤崇宏、川本泰輔、近藤美弥子、秋山廣輔、加賀基知三、平野聡、進藤正信、樋田京子
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2011-10-03
  • [Presentation] 腫瘍血管内皮細胞とがん転移との相互作用解析2011

    • Author(s)
      間石奈湖、大賀則孝、樋田泰浩、大場雄介、浜田淳一、秋山廣輔、山本和幸、大澤崇宏、近藤美弥子、川本泰輔、井上農夫男、樋田京子
    • Organizer
      第20回日本がん転移学会学術集会・総会
    • Place of Presentation
      アクトシティ浜松(浜松)
    • Year and Date
      2011-06-30
  • [Presentation] Analysis ofinteraction between tumor endothelial cells and tumor cells2010

    • Author(s)
      間石奈湖、大賀則孝、樋田泰浩、大場雄介、秋山廣輔、北山和子、近藤美弥子、川本泰輔、大澤崇宏、山本和幸、井上農夫男、進藤正信、樋田京子
    • Organizer
      第18回日本血管生物医学会学術集会
    • Place of Presentation
      梅田スカイビル(大阪)
    • Year and Date
      20101201-03
  • [Presentation] 腫瘍血管内皮細胞と腫瘍細胞との相互作用解析2010

    • Author(s)
      間石奈湖、大賀則孝、黒須拓郎、秋山廣輔、石川修平、近藤美弥子、川本泰輔、樋田泰浩、井上農夫男、樋田京子
    • Organizer
      第19回日本がん転移学会学術集会・総会
    • Place of Presentation
      金沢市文化ホール(金沢)
    • Year and Date
      20100616-17
  • [Book] 血管生物医学事典2011

    • Author(s)
      樋田京子:佐藤靖史、森田育男、高倉伸幸、小室一成監修
    • Total Pages
      206-209
    • Publisher
      朝倉書店
  • [Remarks]

    • URL

      http://www.den.hokudai.ac.jp/vascular-biology/publications.html

URL: 

Published: 2013-07-31  

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