2011 Fiscal Year Final Research Report
Mechanism of premetastatic niche formation and promotion of metastasis by cancer mesenchymal cells
Project/Area Number |
21591655
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Hokkaido University |
Principal Investigator |
HIDA Yasuhiro 北海道大学, 北海道大学病院, 講師 (30399919)
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Co-Investigator(Kenkyū-buntansha) |
HIDA Kyoko 北海道大学, 大学院・歯学研究科, 特任准教授 (40399952)
KONDO Satoshi 北海道大学, 大学院・医学研究科, 教授 (30215454)
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Project Period (FY) |
2009 – 2011
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Keywords | 癌 / 転移 / 血管新生 / 血管内皮細胞 / ニッシェ |
Research Abstract |
Promotion of lung metastasis by interaction between tumor and tumor endothelial cells In this study, it was shown that tumor endothelial cells promote invasion and metastasis of tumor cells using cells labeled with fluorescein proteins. Tumor cells inoculated to mice with tumor endothelial cells circulated in peripheral blood and metastasized to lungs more than control conditions. The mechanism are enhanced migration of tumor cells towards tumor endothelial cells and transendothelial migration.
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Research Products
(22 results)
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[Journal Article] Tumor-Derived Microvesicles Induce Proangiogenic Phenotype in Endothelial Cells via Endocytosis2012
Author(s)
Kawamoto T, Ohga N, Akiyama K, Hirata N, Kitahara S, Maishi N, Osawa T, Yamamoto K, Kondoh M, Shindoh M, Hida Y, Hida K.
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Journal Title
PLoS One
Volume: 7(3)
Pages: e34045
Peer Reviewed
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[Journal Article] Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner2012
Author(s)
Osawa T, Ohga N, Hida Y, Kitayama K, Akiyama K, Onodera Y, Fujie M, Shinohara N, Shindoh M, Nonomura K, Hida K
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Biglycan is a aspecific marker and an autocrine angiogenic factor of tumour endothelial cells2012
Author(s)
Yamamoto K, Ohga N, Hida Y, Maishi N, Kawamoto T, Kitayama K, Akiyama K, Osawa T, Kondoh M, Matsuda K, Onodera Y, Fujie M, Kaga K, Hirano S, Shinohara N, Shindoh M, Hida K.
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Journal Title
Br J Cancer
Volume: 106(6)
Pages: 1214-23
DOI
Peer Reviewed
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[Journal Article] Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment2012
Author(s)
Akiyama K, Ohga N, Hida Y, Kawamoto T, Sadamoto Y, Ishikawa S, Maishi N, Akino T, Kondoh M, Matsuda A, Inoue N, Shindoh M, Hida K.
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Journal Title
Am J Pathol
Volume: 180(3)
Pages: 1283-93
Peer Reviewed
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[Journal Article] Heterogeneity of tumor endothelial cells : comparison between tumor endothelial cells isolated from high-and low-metastatic tumors2012
Author(s)
Ohga N, Ishikawa S, Maishi N, Akiyama K, Hida Y, Kawamoto T, Sadamoto Y, Osawa T, Yamamoto K, Kondoh M, Ohmura H, Shinohara N, Nonomura K, Shindoh M, Hida K.
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Journal Title
Am J Pathol
Volume: 180(3)
Pages: 1297-307
Peer Reviewed
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[Journal Article] Adrenomedullin antagonist suppresses tumor formation in renal cell carcinoma through inhibitory effects on tumor endothelial cells and endothelial progenitor mobilization2010
Author(s)
Tsuchiya K, Hida K, Hida Y, Muraki C, Ohga N, Akino T, Kondo T, Miseki T, Nakagawa K, Shindoh M, Harabayashi T, Shinohara N, Nonomura K, Kobayashi M.
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Journal Title
Int J Oncol
Volume: 36(6)
Pages: 1379-86
Peer Reviewed
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[Journal Article] Isolated tumor endothelial cells maintain specific character during long-term culture2010
Author(s)
Matsuda K, Ohga N, Hida Y, Muraki C, Tsuchiya K, Kurosu T, Akino T, Shih SC, Totsuka Y, Klagsbrun M, Shindoh M, Hida K.
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Journal Title
Biochem Biophys Res Commun
Volume: 394(4)
Pages: 947-54
Peer Reviewed
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[Presentation] Biglycan is a specific marker and an autocrine angiogenic factor of tumor endothelial cells2012
Author(s)
Yamamoto K., Ohga N., Hida Y., Maishi N., Kawamoto T., Kitayama K., Akiyama K., Osawa T., Kondoh M., Kaga K., Hirano S., Shinohara N., Shindoh M., Hida K.
Organizer
AACR ANNUAL MEETING 2012
Place of Presentation
Chicago, Illinois
Year and Date
2012-04-02
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[Presentation] Analysis of interaction between tumor endothelial cells and tumor cells2011
Author(s)
Maishi N., Ohga N., Hida Y., Ohba Y., Kawamoto T., Akiyama K., Kitayama K., Kondoh M., Ohsawa T., Yamamoto K., Inoue N., Shindoh M., Hida K.
Organizer
AACR 102^<nd> ANNUAL MEETING 2011
Place of Presentation
Orlando, Florida
Year and Date
20110402-06
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