2011 Fiscal Year Final Research Report
Analysis of a novel BRCA1-associated protein for new cancer therapy
Project/Area Number |
21591656
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Tohoku University |
Principal Investigator |
CHIBA Natsuko 東北大学, 加齢医学研究所, 准教授 (50361192)
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Co-Investigator(Renkei-kenkyūsha) |
KANNO Shin-ichiro 東北大学, 加齢医学研究所, 講師 (10400417)
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Project Period (FY) |
2009 – 2011
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Keywords | 乳癌 / 化学療法 / 標的分子 / バイオマーカー |
Research Abstract |
Germline mutations in the breast cancer susceptibility gene BRCA1 predispose women to breast and ovarian cancers. BRCA1 plays important roles in DNA repair and centrosome regulation, along with its heterodimer partner BARD1. We identified a new protein that interacts with BARD1 (here we call it BARD1-interacting protein (BIP)). We found that BIP plays an important role in the regulation of centrosome amplification and cytokinesis together with BRCA1and BARD1.
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[Journal Article] BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein.2011
Author(s)
Wei L, Lan L, Yasui A, Tanaka K, Saijo M, Matsuzawa A, Kashiwagi R, Maseki E, Hu Y, Parvin J D, Ishioka C and Chiba N
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Journal Title
Cancer Science
Volume: 102(10)
Pages: 1840-7
DOI
Peer Reviewed
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[Presentation] A novel BARD1-interacting protein regulates centrosome and cytokinesis.2011
Author(s)
Matsuzawa A, Shibata S, Mochiduki H, Maseki E, , Furukawa Y, Kato K, Shiono M, and Chiba N
Organizer
5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
Place of Presentation
National University of Singapore, Singapore, Singapore
Year and Date
2011-12-12
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[Presentation] Regulation of the level of BRCA1/BARD1 expression.2011
Author(s)
Maseki E, Shiono M, Matsuzawa A, Furukawa Y, Shibata S, Mochiduki H, Kato K, and Chiba N
Organizer
5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
Place of Presentation
National University of Singapore, Singapore, Singapore
Year and Date
2011-12-12
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[Presentation] Function of BRCA1 in DNA damage repair and centrosome regulation.2011
Author(s)
Chiba N, Matsuzawa A, Kashiwagi R, Maseki E, Kanno S, Wei L, Furukawa Y, Shibata S, Ishioka C, and Yasui A
Organizer
The 6th International Symposium of Institute Network
Place of Presentation
Tokyo, Japan
Year and Date
2011-06-09
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[Presentation] Identification of a novel BARD1-interacting protein and analyses of its function.2010
Author(s)
Matsuzawa A, Kanno S, Wei L, Kashiwagi R, Maseki E, Shibata S, Furukawa Y, Ishioka C, Yasui A, and Chiba N
Organizer
4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
Place of Presentation
National University of Singapore, Singapore, Singapore
Year and Date
2010-12-16
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