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2011 Fiscal Year Final Research Report

Analysis of a novel BRCA1-associated protein for new cancer therapy

Research Project

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Project/Area Number 21591656
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionTohoku University

Principal Investigator

CHIBA Natsuko  東北大学, 加齢医学研究所, 准教授 (50361192)

Co-Investigator(Renkei-kenkyūsha) KANNO Shin-ichiro  東北大学, 加齢医学研究所, 講師 (10400417)
Project Period (FY) 2009 – 2011
Keywords乳癌 / 化学療法 / 標的分子 / バイオマーカー
Research Abstract

Germline mutations in the breast cancer susceptibility gene BRCA1 predispose women to breast and ovarian cancers. BRCA1 plays important roles in DNA repair and centrosome regulation, along with its heterodimer partner BARD1. We identified a new protein that interacts with BARD1 (here we call it BARD1-interacting protein (BIP)). We found that BIP plays an important role in the regulation of centrosome amplification and cytokinesis together with BRCA1and BARD1.

  • Research Products

    (30 results)

All 2012 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (19 results) Book (6 results) Remarks (1 results)

  • [Journal Article] Functional differences among BRCA1 missense mutations in the control of centrosome duplication.2012

    • Author(s)
      Kais Z, Chiba N, Ishioka C, Parvin J D
    • Journal Title

      Oncogene

      Volume: 31(6) Pages: 799-804

    • DOI

      doi:10.1038/onc.2011.271

    • Peer Reviewed
  • [Journal Article] BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein.2011

    • Author(s)
      Wei L, Lan L, Yasui A, Tanaka K, Saijo M, Matsuzawa A, Kashiwagi R, Maseki E, Hu Y, Parvin J D, Ishioka C and Chiba N
    • Journal Title

      Cancer Science

      Volume: 102(10) Pages: 1840-7

    • DOI

      doi:10.1111/j.1349-7006.2011.02037.x

    • Peer Reviewed
  • [Journal Article] Identifying the effect of BRCA1 mutations on homologous recombination using cells that express endogenous wild-type2011

    • Author(s)
      Parvin J D, Chiba N, and Ransburgh D
    • Journal Title

      BRCA1

      Volume: 48 Pages: e2468

    • DOI

      doi:10.3791/2468

    • URL

      http://www.jove.com/index/Details.stp?ID=2468J.Vis.Exp

    • Peer Reviewed
  • [Journal Article] Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination.2010

    • Author(s)
      Ransburgh D, Chiba N, Ishioka C, Toland A, and Parvin J D
    • Journal Title

      Cancer Research

      Volume: 70(3) Pages: 988-95

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/20103620

    • Peer Reviewed
  • [Presentation] Analysis of Tumor Suppressor BRCA1 using Molecular Imaging.2012

    • Author(s)
      Chiba N, Furukawa Y, Shibata S, Kato K, Mochiduki H, Shiono M, Maseki E, and Matsuzawa A
    • Organizer
      The 18th International Symposium on Nano-Biomedical
    • Place of Presentation
      Engineering in the East Asian-Pacific Rim Region (Sendai, Japan)
    • Year and Date
      2012-03-06
  • [Presentation] A novel BARD1-interacting protein regulates centrosome and cytokinesis.2011

    • Author(s)
      Matsuzawa A, Shibata S, Mochiduki H, Maseki E, , Furukawa Y, Kato K, Shiono M, and Chiba N
    • Organizer
      5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
    • Place of Presentation
      National University of Singapore, Singapore, Singapore
    • Year and Date
      2011-12-12
  • [Presentation] Regulation of the level of BRCA1/BARD1 expression.2011

    • Author(s)
      Maseki E, Shiono M, Matsuzawa A, Furukawa Y, Shibata S, Mochiduki H, Kato K, and Chiba N
    • Organizer
      5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
    • Place of Presentation
      National University of Singapore, Singapore, Singapore
    • Year and Date
      2011-12-12
  • [Presentation] SNPs of Aurora-A are involved in the centrosome regulation of BRCA1 and malignant potential of esophageal cancer. Aurora-Aの一塩基多型はBRCA1による中心体制御と食道癌の悪性度に関与する。2011

    • Author(s)
      Matsuzawa A, Mori T, Mochiduki H, Chiba N
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] Function of BRCA1 in DNA damage repair and centrosome regulation.2011

    • Author(s)
      Chiba N, Matsuzawa A, Kashiwagi R, Maseki E, Kanno S, Wei L, Furukawa Y, Shibata S, Ishioka C, and Yasui A
    • Organizer
      The 6th International Symposium of Institute Network
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2011-06-09
  • [Presentation] Identification of a novel BARD1-interacting protein and analyses of its function.2010

    • Author(s)
      Matsuzawa A, Kanno S, Wei L, Kashiwagi R, Maseki E, Shibata S, Furukawa Y, Ishioka C, Yasui A, and Chiba N
    • Organizer
      4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
    • Place of Presentation
      National University of Singapore, Singapore, Singapore
    • Year and Date
      2010-12-16
  • [Presentation] Regulatory mechanism of the level of BRCA1/BARD1 expression following DNA damage.2010

    • Author(s)
      aseki E, Kanno S, Matsuzawa A, Kashiwagi R, Furukawa Y, Shibata S, Yasui A, and Chiba N
    • Organizer
      4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
    • Place of Presentation
      National University of Singapore, Singapore, Singapore
    • Year and Date
      2010-12-16
  • [Presentation] BRCA1はDNA単鎖切断修復に関与する2010

    • Author(s)
      柏木梨佐、古川裕美子、宇井彩子、松澤綾子、柵木絵美子、柴田峻、石岡千加史、安井明、千葉奈津子
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
  • [Presentation] Regulatory mechanism of the level of BRCA1/BARD1 expression following DNA damage2010

    • Author(s)
      Maseki E, Kanno S, Matsuzawa A, Kashiwagi R, Shibata S, Furukawa Y, Wei L, Ishioka C, Yasui A, and Chiba N
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
  • [Presentation] Identification of a novel BARD1-interacting protein that regulates centrosome and cytokinesis中心体と細胞質分裂を制御する新規BARD1結合分子の同定2010

    • Author(s)
      Matsuzawa A, Wei L, Kashiwagi R, Maseki E, Ishioka C, Yasui A, and Chiba N
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
  • [Presentation] The effect of BRCA1 missense mutations on homology directed recombination, BRCA1の点突然変異の相同組み換えへの影響2010

    • Author(s)
      Chiba N, Matsuzawa A, Kashiwagi R, Maseki E and Ishioka C
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
  • [Presentation] A novel BARD1-interacting protein functions at cell cycle regulation.2010

    • Author(s)
      Matsuzawa A, Kanno S, Wei L, Kashiwagi R, Maseki E, Ishioka C, Yasui A, and Chiba N
    • Organizer
      6th World Congress of Biomechanics
    • Place of Presentation
      Suntec City, Singapore, Singapore
    • Year and Date
      2010-08-03
  • [Presentation] Regulation of BRCA1/BARD1 expression after DNA damage.2010

    • Author(s)
      Maseki E, Kanno S, Matsuzawa A, Kashiwagi R, Wei L, Ishioka C, Yasui A, and Chiba N
    • Organizer
      6th World Congress of Biomechanics
    • Place of Presentation
      Suntec City, Singapore, Singapore
    • Year and Date
      2010-08-03
  • [Presentation] Analysis of tumor suppressor gene using Molecular imaging technique for personalized medicine.2010

    • Author(s)
      Chiba N, Kashiwagi R, Maseki E, and Matsuzawa A
    • Organizer
      The 12th Internatopnal Symposium on Nano-Biomedical Engineering in the East Asian-Pacific Rim Region
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2010-03-26
  • [Presentation] A novel BARD1-interacting protein functions at spindle poles and midbody to regulate mitosis and cytokinesis.2009

    • Author(s)
      松澤綾子、菅野新一郎、魏雷震、柏木梨佐、柵木絵美子、石岡千加史、安井明、千葉奈津子
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
  • [Presentation] BRCA1のコケイン症候群CSB蛋白のユビキチン化と転写共役修復への影響2009

    • Author(s)
      千葉奈津子、魏雷震、田中亀代次、石岡千加史、安井明
    • Organizer
      第20回DNA複製・組み換え・修復ワークショップ
    • Place of Presentation
      滋賀県彦根市
    • Year and Date
      2009-11-01
  • [Presentation] BRCA1のDNA単鎖切断修復能における機能2009

    • Author(s)
      柏木梨佐、魏雷震、松澤綾子、柵木絵美子、石岡千加史、安井明、千葉奈津子
    • Organizer
      第20回DNA複製・組み換え・修復ワークショップ
    • Place of Presentation
      滋賀県彦根市
    • Year and Date
      2009-11-01
  • [Presentation] BRCA1 polyubiquitinates CSB protein in transcription-coupled repair of UV damage、転写と共役したDNA修復においてBRCA1がコケイン症候群CSB蛋白をユビキチン化する2009

    • Author(s)
      千葉奈津子, 魏雷震, 田中亀代次, 安井明, 石岡千加史
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-10-03
  • [Presentation] Identification of a new target of cancer therapy by a proteomic study. The 10th Internatopnal Symposium on Nano-Biomedical Engineering2009

    • Author(s)
      Chiba N, Matsuzawa A, Wei L, Kashiwagi R, Maseki E, Yasui A, and Kanno S
    • Organizer
      in the East Asian-Pacific Rim Region
    • Place of Presentation
      Christchurch, New Zealand
    • Year and Date
      2009-04-16
  • [Book] BRCA1 is involved in the transcription-coulpled repair of UV lesions. Nano-Biomedical Engineering 20112012

    • Author(s)
      Chiba N and Wei L
    • Total Pages
      509-519
    • Publisher
      Imperial College Press
  • [Book] Regulation of BRCA1 and BARD1 expression levels in Response to DNA damageNano-Biomedical Engineering 20112012

    • Author(s)
      Maseki E, Shiono M, Matsuzawa A, Wei L, Kashiwagi R, Furukawa Y, Shibata S, Mochiduki H, Kato K, and Chiba N.
    • Total Pages
      613-618
    • Publisher
      Imperial College Press
  • [Book] Identification of a novel BARD1-interacting protein and an analysis of its function in the regulation of mitosis. Nano-Biomedical Engineering 20112012

    • Author(s)
      Matsuzawa A, Wei L, Kashiwagi R, Shibata S, Mochiduki H, Maseki E, Furukawa Y, Kato K, Shiono M, and Chiba N.
    • Total Pages
      619-624
    • Publisher
      Imperial College Press
  • [Book] BRCA1 responds to DNA damage induced by laser-irradiation. Nano-Biomedical Engineering 20112012

    • Author(s)
      Wei L, Kashiwagi R, Furukawa Y, Kato K, and Chiba N.
    • Total Pages
      655-660
    • Publisher
      Imperial College Press
  • [Book] Analysis of Tumor Suppressor Gene Using Molecular Imaging for Personalized Medicine, Nano-Biomedical Engineering 20092009

    • Author(s)
      Chiba N and Wei L
    • Total Pages
      339-349
    • Publisher
      Imperial College Press
  • [Book] Analysis of BRCA1 Accumulation at DNA Double-Strand Breaks Using a Molecular Imaging technique, Nano-Biomedical Engineering 20092009

    • Author(s)
      Wei L and Chiba N
    • Total Pages
      459-465
    • Publisher
      Imperial College Press
  • [Remarks]

    • URL

      http://www.lifesci.tohoku.ac.jp/research/field_list/neurogenetics/ts_nchiba

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Published: 2013-07-31  

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