2011 Fiscal Year Final Research Report
Experimental and Clinical studies of repair of intra-thoracic autonomic nerves using chitosan tubes
| Project/Area Number |
21591661
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ODA Makoto 金沢大学, 医学系, 准教授 (50224241)
WATANABE Go 金沢大学, 医学系, 教授 (60242492)
TAMURA Masaya 金沢大学, 附属病院, 助教 (10397185)
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| Project Period (FY) |
2009 – 2011
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| Keywords | キトサン / 神経再生 / 横隔神経 / 迷走神経 / 交感神経 |
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| Research Abstract |
We investigated the safety and usefulness of chitosan nano/microfiber mesh tubes(C-tube) in regenerating damaged thoracic autonomic nerves. Animal experiments were performed using beagle dogs. The thoracic sympathetic nerve and phrenic nerve were resected and sutured with C-tubes. After surgery, all dogs survived without complication throughout the observational period. At1year after surgery, the nerves were connected in C-tube, and in some dogs the symptoms due to each damaged nerve were recovered. C-tubes can be safely used to facilitate the regeneration of damaged sympathetic and phrenic nerves and the restoration of their lost functions.
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