2011 Fiscal Year Final Research Report
Oncolytic Virus Therapy using Hitch hike method on Lymphocyte
| Project/Area Number |
21591662
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
KASUYA Hideki 名古屋大学, 大学院・医学系研究科, 准教授 (00402636)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Akimasa 名古屋大学, 大学院・医学系研究科, 教授 (70164754)
TAKEDA Shin 名古屋大学, 大学院・医学系研究科, 講師 (20314015)
SUGIMOTO Hiroyuki 名古屋大学, 医学部附属病院, 助教 (20437007)
NOMOTO Shuji 名古屋大学, 医学部附属病院, 病院講師 (40300967)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 癌 / ウイルス / 転移性肝癌 / 腫瘍溶解性ウイルス / HF10 |
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| Research Abstract |
We have researched new methodology using anti tumor lymphocyte for delivering oncolytic virus R3616. Adsorbed R3616 on tumor antigen specific lymphocyte reached target tumor, and infected to tumor cells. This anti tumor effect has statistic different from adsorbed R3616 on tumor antigen non-specific lymphocyte. We acquired precious basic data for clinical trial.
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[Journal Article] Antitumor efficacy of oncolytic her pessimplex virus adsorbed on to antigen-specific lymphocytes.2011
Author(s)
Kanzaki A, Kasuya H, Yamamura K, Sahin TT, Nomura N, Shikano T, Shirota T, Tan G, FukudaS, Misawa M, Nishikawa Y, Yamada S, Fujii T, Sugimoto H, Nomoto S, Takeda S, Kodera Y, Nakao A.
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Journal Title
Peer Reviewed
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[Journal Article] Oncolytic herpes virus induces effective anti-cancer immunity against murine colon cancer.2011
Author(s)
Shirota T, Kasuya H, Kodera Y, Nishikawa Y, Shikano T, Sahin TT, Gewen T, Yamamura K, Fukuda S, Kanzaki A, Yamada S, Fujii T, Sugimoto H, Nomoto S, Takeda S, Nakao A.
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Journal Title
He pato gastroenterology
Volume: No.1
Pages: 110-111
Peer Reviewed
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[Journal Article] Combination of the Tumor Angiogenesis Inhibitor Bevacizumab and Intratumoral Oncolytic Herpes Virus Injections as a Treatment Strategy for Human Gastric Cancers2011
Author(s)
Sahin TT, Kasuya H, Nomura N, Sh. kano H, Yamamura K, Gewen T, Kanzaki A, Fujii T, Sugae T, Imai T, Nomoto S, Takeda S, Sugimoto H, Kikumori T, Kodera Y, Nishiyama Y, Nakao A.
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Journal Title
Peer Reviewed
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[Journal Article] A phase I dose-escalation clinical trial of intraoperative direct in tratumoral injection of HF10 oncolytic virus innon-resectable patients with advanced pancreatic cancer2011
Author(s)
Nakao A, Kasuya H, Sahin TT, Nomura N, Kanzaki A, Misawa M, Shirota T, Yamada S, Fujii T, Sugimoto H, Shikano T, Nomoto S, Takeda S, Kodera Y, Nishiyama Y.
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Journal Title
Cancer Gen Ther
Volume: No.3
Pages: 167-175
Peer Reviewed
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[Journal Article] High the rapeutic potential for systemic delivery of aliposo me-conjugated herpes simplex virus2010
Author(s)
Shikano T, Kasuya H, Sahin TT, Nomura N, Kanzaki A, Misawa M, Nishikawa Y, Shirota T, Yamada S, Fujii T, Sugimoto H, Kanazumi N, Nomoto S, Takeda S, Nakao A.
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Journal Title
Cur Cancer Drug Targets
Volume: No.1
Pages: 111-122
Peer Reviewed
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[Journal Article] Considerations for intravascular administration of oncolytic herpesvirus for the treatment of multiple live rmetastases2009
Author(s)
Nomura N, Kasuya H, Watanabe I, Shikano T, Shirota T, Misawa M, Sugimoto H, Kanazumi N, Nomoto S, Takeda S, Nakao A.
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Journal Title
Cancer Chemother Pharmacol
Volume: Vol.63, No.2
Pages: 32-330
Peer Reviewed
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