2011 Fiscal Year Final Research Report
Development of treatment for papillary and anaplastic thyroid carcinoma by targeting cancer-specific aberrant protein
| Project/Area Number |
21591663
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Yoshitaka 名古屋大学, 環境医学研究所, 准教授 (80420363)
KOBAYASHI Takeshi 中部大学, 生物機能開発研究所, 客員教授 (10043324)
NAKAO Akimasa 名古屋大学, 大学院・医学系研究科, 教授 (70164754)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | BRAF / 甲状腺癌 / 温熱治療 / ヒートショック蛋白 |
|---|
| Research Abstract |
Suppression of BRAF expression in human anaplastic thyroid carcinoma cell line NPA, human papillary thyroid carcinoma cell line K1 those have BRAF mutation which is involved in malignant transformation and papillary thyroid carcinoma cell line TPC1 without BRAF mutation reduced expression of genes related to malignant transformation. In clinical thyroid carcinoma specimen, approximately 90% of cases have mutation in BRAF activating mutation. HSP90 inhibitor which is anticipated to reduce BRAF expression inhibits cell proliferation in other cancer cell lines.
|
