2011 Fiscal Year Final Research Report
Anti-cancer immunotherapy targeting toll-like receptors expressed on cancer cells and killer T cells
| Project/Area Number |
21591668
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 癌 / 免疫療法 / Toll様受容体 |
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| Research Abstract |
In this study, we revealed that apoptosis and growth arrest in a LNCaP human prostate cancer cell line can be induced by the addition of poly(I : C). In addition, transfection of poly(I : C) induced apoptosis and growth arrest in all three human breast cancer cell lines tested. Give that poly(I : C) can stimulate the immune response, these results indicate that poly(I : C) can induce anti-tumor effects and the stimulation of immune system simultaneously.
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