2011 Fiscal Year Final Research Report
Study for mechanism of cell cycle regulation by ubiquitin ligase in triple-negative breast cancer
| Project/Area Number |
21591671
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
YAMAMOTO Yutaka 熊本大学, 大学院・生命科学研究部, 助教 (20398217)
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| Co-Investigator(Kenkyū-buntansha) |
IWASE Hirotaka 熊本大学, 大学院・生命科学研究部, 教授 (40211065)
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| Research Collaborator |
IBUSUKI Mutsuko 熊本大学, 大学院・生命科学研究部, 助教 (30448526)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 乳腺外科学 / ユビキチンリガーゼ / Fbw7 / skp2 |
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| Research Abstract |
We studied clinical significance of ubiquitin ligase(skp2 and Fbw7) in breast cancer and potential of ubiquitin ligase targeting-therapy for breast cancer. Fbw7 downregulation and skp2 overexpression were significantly correlated with aggressive phenotype in breast cancer. Fbw7 knockdown led to suppression of proliferation in breast cancer cells.
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