2011 Fiscal Year Final Research Report
Mechanisms of sulforaphane-induced breast cancer cell death via autophagy and its application in cancer treatment
| Project/Area Number |
21591683
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kansai Medical University |
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Principal Investigator |
TSUBURA Airo 関西医科大学, 医学部, 教授 (90098137)
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| Co-Investigator(Kenkyū-buntansha) |
UEHARA Norihisa 関西医科大学, 医学部, 講師 (30368211)
YURI Takashi 関西医科大学, 医学部, 講師 (50330212)
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| Project Period (FY) |
2009 – 2011
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| Keywords | スルフォラファン / 乳癌 / アポトーシス / オートファジー / 細胞死 / バフィロマイシン / 3-メチルアデニン |
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| Research Abstract |
Sulforaphane(SFN) significantly inhibited primary tumor growth and tended to reduce axillary lymph node metastasis of KPL-1 human breast cancer cell xenografts in female athymic mice with no side effects. The involvement of autophagy in the SFN-induced apoptotic cell death of MCF-7 and MDA-MB-231 human breast cancer cells was cytoprotective. Therefore, SFN is safe and the combination of SFN with autophagy inhibitor may be a promising strategy for breast cancer control.
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