• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

Molecular mechanism of solid tumor growth inhibition by a new differentiation inducer and rapamycin

Research Project

  • PDF
Project/Area Number 21591686
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionResearch Institute for Clinical Oncology, Saitama Cancer Center

Principal Investigator

KASUKABE Takashi  埼玉県立がんセンター, 臨床腫瘍研究所, 主幹 (50152658)

Project Period (FY) 2009 – 2011
KeywordsCotylenin A / Rapamycin / 分化誘導剤 / 乳癌細胞 / 増殖抑制 / 併用効果 / Aktリン酸化 / mTOR
Research Abstract

We have examined whether a new differentiation inducer of leukemic cells can suppress the proliferation of solid tumor cells. We recently found that cotylenin A and rapamycin synergistically inhibited the growth of human mammary cancer cells in vitro and in vivo. In this study we found that the abrogation by cotylenin of the rapamycin-induced feedback activation of Akt signaling contributed, at least in part, to the synergistic growth inhibition of mammary cancer cells induced by treatment with cotylenin A and rapamycin.

  • Research Products

    (8 results)

All 2012 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Extracellular NM23 protein as a therapeutic target for hematological malignancy2012

    • Author(s)
      Okabe-Kado, J., Kasukabe, T., Kaneko, Y.
    • Journal Title

      Adv. Hematol

      Volume: 2012 Pages: 879368

    • DOI

      DOI:10.1155/2012/87968

    • Peer Reviewed
  • [Journal Article] Ellagic acid, a natural polyphenolic compound, induces apoptosis and potentiates retinoic acid-induced differentiation of human leukemia HL-60 cells2010

    • Author(s)
      Hagiwara, Y., Kasukabe, T., Kaneko, Y., Niitsu, N., Okabe-Kado, J.
    • Journal Title

      J. Hematol

      Volume: 92 Pages: 136-143

    • Peer Reviewed
  • [Journal Article] Extracellular NM23 protein promotes the growth and survival of primary cutured human acute myelogenous leukemia cells2009

    • Author(s)
      Okabe-Kado, J., Kasukabe, T., Honma, Y., Kobayashi, H., Kaneko, Y.
    • Journal Title

      Cancer Sci

      Volume: 100 Pages: 1885-1894

    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Okabe-Kado, J., Kasukabe, T., Honma, Y., Kobayashi, H., Maseki, N., Kaneko, Y
    • Journal Title

      Int. J. Hematol

      Volume: 90 Pages: 143-152

    • Peer Reviewed
  • [Presentation] Cotylenin A potentiates arsenic trioxide-induced apoptosis in human breast cancer cells2011

    • Author(s)
      粕壁隆, 他2名
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
  • [Presentation] PI-103 and cotylenin A synergistically inhibit growth of rapamycin-sensitive and-resistant mammary cancer cells2010

    • Author(s)
      粕壁隆, 他2名
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
  • [Presentation] Rapamycin and arsenic trioxide synergistically induce apoptosis of human ovarian cancer cells2009

    • Author(s)
      粕壁隆, 他3名
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
  • [Remarks]

    • URL

      http://www.pref.saitama.lg.jp/A80/BA02/top.htm

URL: 

Published: 2013-07-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi