2011 Fiscal Year Final Research Report
Diversity of imatinib-resistance clones in gastrointestinal stromal tumors
| Project/Area Number |
21591694
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
KANDA Tatsuo 新潟大学, 医歯学系, 講師 (80303147)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AJIOKA Yoichi 新潟大学, 医歯学系, 教授 (80222610)
HIROTA Seiichi 兵庫医科大学, 医学部, 教授 (50218856)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | GIST / 遺伝子分析 / イマチニブ / 耐性 / KIT遺伝子 |
|---|
| Research Abstract |
We addressed clonal diversity of imatinib-resistant gastrointestinal stromal tumors(GIST) using histological and genomic approaches. Of 27 imatinib-resistant GIST, 20 tumors(74. 1%) were composed of foci that showed morphologically different appearance. Although PCR samples were retrieved from the 66 tumor foci using a microdissection technique, KIT gene analysis was capable in only 20 foci(30. 3%).
|
