2011 Fiscal Year Final Research Report
Effect of DNA methylation on the regulation of microRNA in squamous cell carcinoma of the esophagus
| Project/Area Number |
21591704
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
BABA Hideo 熊本大学, 大学院・生命科学研究部, 教授 (20240905)
KAMOHARA Hidenobu 熊本大学, 大学院・生命科学研究部, 准教授 (90398222)
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| Project Period (FY) |
2009 – 2011
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| Keywords | DNAメチル化異常 / SYBR green法 / microRNA / ホルマリン固定標本 / 化学療法感受性 / 食道癌 |
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| Research Abstract |
We clarified that global hypomethylation was observed in squamous cell carcinoma of the esophagus(ESCC) and the hypomethylation of LINE-1 was a significant indicator for poor prognosis in patients with ESCC. We also identified that overexpression of microRNA(miR)-29c was a prognostic factor of patients with ESCC and miR-223 regulated FBXW7 in ESCC. We examined miR-21 expression in the serum and clarified that the serum miR-21 levels of ESCC patients was significantly higher than those of healthy controls and the serum miR-21 expression could be a marker for treatment effect for ESCC.
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[Journal Article] Pyrosequencing Assay to Measure LINE-1 Methylation Level in Esophageal Squamous Cell Carcinoma2012
Author(s)
Iwagami S, Baba Y, Watanabe M, Shigaki H, Miyake K, Ida S, Nagai Y, Takatsugu I, Iwatsuki M, Sakamoto Y, Miyamoto Y, Baba H
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Journal Title
Annals of Surgical Oncology
Volume: (印刷中)
Peer Reviewed
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[Journal Article] MicroRNA-200b regulates cell proliferation, invasion and migration by directly targeting ZEB2 in gastric carcinoma2012
Author(s)
Kurashige J, Kamohara H, Watanabe M, Hiyoshi Y, Iwatsuki M, Tanaka Y, Kinoshita K, Saito S, Baba Y, Baba H
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Journal Title
Ann Surg Oncol
Volume: (印刷中)
Peer Reviewed
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[Journal Article] Induction chemotherapy with docetaxel/cisplatin/5-fluorouracil for patients with node-positive esophageal cancer2011
Author(s)
Watanabe M, Nagai Y, Kinoshita K, Saito S, Kurashige J, Karashima R, Hirashima K, Sato N, Imamura Y, Hiyoshi Y, Baba Y, Iwagami S, Miyamoto Y, Iwatsuki M, Hayashi N, Baba H
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Journal Title
Digestion
Volume: 83巻
Pages: 146-152
Peer Reviewed
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