2011 Fiscal Year Final Research Report
Identification of EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma and elucidation of its regulation mechanism.
| Project/Area Number |
21591706
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUMOTO Shoichi 広島大学, 広島大学病院, 助教 (00532631)
KITANO Seigo 大分大学, 学長 (90169871)
ETOH Tsuyoshi 大分大学, 医学部, 講師 (00404369)
HIYAMA Keiko 広島大学, 原爆放射線医科学研究所, 准教授 (60253069)
TANIMOTO Keiji 広島大学, 原爆放射線医科学研究所, 助教 (90335688)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 食道外科学 / 癌抑制遺伝子 |
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| Research Abstract |
This study demonstrates the possibility of EMP3 as a candidate tumor suppressor gene for esophageal squamous cell carcinoma(ESCC). The conditions for EMP3 Immunohistochemistry were not known, so we tried to evaluate the specific conditions for the assay. We did a genome wide profiling analysis using oligonucleotide microarray, were EMP3 overexpression in ESCC cells showed novel candidate down-stream target genes. In order to assess the regulatory mechanisms of the EMP3 gene, we constructed deletion mutants in the proximal promoter region.
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