Treatment strategy for micro-lymph node metastases using anti-tumoral immunological mechanism

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591707
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kagoshima University
• Principal Investigator: ISHIGAMI Sumiya 鹿児島大学, 歯学部附属病院, 講師 (90325803)
• Co-Investigator(Kenkyū-buntansha): NATSUGOE Shoji 鹿児島大学, 大学院・医歯学総合研究科, 教授 (70237577) ; NAKAJO Akihiro 鹿児島大学, 医学部・歯学部附属病院, 助教 (20404486) ; KITAZONO Masaki 鹿児島大学, 医学部・歯学部附属病院, 助教 (30398276)
• Project Period (FY): 2009 – 2011
• Keywords: リンパ節転移 / 抗腫瘍免疫機構 / リンパ節転移モデル / ケモカイン

Research Abstract

We tried to clarify the association between chemokine expression and clinicopathological factors in gastrointestinal cancer, moreover we investigated how host immune function affect for micro lymph node metastases using mouse model. We showed the expression of CD166 and CD168 in gastric cancer positively correlated with clinical factors and was selected as prognostic marker in gastric cancer for the first time. We could establish micro lymph node metastases model using GFP transfected B17F1 and C57BL.

Research Products

• [Journal Article] Endoscopic ultrasonography is useful for monitoring the tumor response of neoadjuvant chemoradiation therapy in esophageal squamous cell carcinoma (2012)
  • Author(s): Owaki T, Matsumoto M, Okumura H, Uchicado Y, Kita Y, Setoyama T, Sasaki K, Sakurai T, Omoto I, Shimada M, Sakamoto F, Yoshinaka H, Ishigami S, Ueno S, Natsugoe S.
  • Journal Title: Am J Surg Volume: 203(2) Pages: 191-7
  • Peer Reviewed
• [Journal Article] Clinical implication of CD166 expression in gastric cancer (2011)
  • Author(s): Ishigami S, Ueno S, Arigami T, Arima H, Uchikado Y, Kita Y, Sasaki K, Nishizono Y, Omoto I, Kurahara H, Matsumoto M, Kijima Y, Natsugoe S.
  • Journal Title: J Surg Oncol Volume: 103 Pages: 57-61
  • Peer Reviewed
• [Journal Article] Is delayed liver resection appropriate for patients with metachronous colorectal metastases? (2011)
  • Author(s): Ueno S, Sakoda M, Kurahara H, Iino S, Minami K, Ando K, Mataki Y, Maemura K, Ishigami S, Takumi K, Fukukura Y, Natsugoe S.
  • Journal Title: Ann Surg Oncol Volume: 18 Pages: 1104-9
  • Peer Reviewed
• [Journal Article] Safety and efficacy of early postoperative hyperbaric oxygen therapy with restriction of transfusions in patients with HCC who have undergone partial hepatectomy (2011)
  • Author(s): Ueno S, Sakoda M, Kurahara H, Iino S, Minami K, Ando K, Mataki Y, Maemura K, Ishigami S, Shinchi H, Natsugoe S.
  • Journal Title: Langenbecks Arch Surg Volume: 396(1) Pages: 99-106
  • Peer Reviewed
• [Journal Article] Oncoplastic surgery in Japanese patients with breast cancer close to the areola : partial mastectomy using periareolar mammoplasty : a case report (2011)
  • Author(s): Kijima Y, Yoshinaka H, Hirata M, Mizoguchi T, Ishigami S, Nakajo A, Arima H, Ueno S, Natsugoe S.
  • Journal Title: Case Rep Surg Volume: 121985
  • Peer Reviewed
• [Journal Article] Expression of BMP-7 in human gastric cancer and its clinical significance (2011)
  • Author(s): Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S.
  • Journal Title: Br J Cancer Volume: 104(4) Pages: 714-8
  • Peer Reviewed
• [Journal Article] B7-H3 expression in gastric cancer : a novel molecular blood marker for detecting circulating tumor cells (2011)
  • Author(s): Arigami T, Uenosono Y, Hirata M, Yanagita S, Ishigami S, Natsugoe S.
  • Journal Title: Cancer Sci Volume: 102(5) Pages: 1019-24
  • Peer Reviewed
• [Journal Article] Increased Slug and decreased E-cadherin expression is related to poor prognosis in patients with gastric cancer (2011)
  • Author(s): Uchikado Y, Okumura H, Ishigami S, Setoyama T, Matsumoto M, Owaki T, Kita Y, Natsugoe S.
  • Journal Title: Gastric Cancer Volume: 14(1) Pages: 41-9
  • Peer Reviewed
• [Journal Article] Oncoplastic surgery combining partial mastectomy with breast reconstruction using a free nipple-areola graft for ductal carcinoma in situ in a ptotic breast : report of a case (2011)
  • Author(s): Kijima Y, Yoshinaka H, Hirata M, Mizoguchi T, Ishigami S, Arima H, Nakajo A, Ueno S, Natsugoe S.
  • Journal Title: Surg Today Volume: 41(3) Pages: 390-5
  • Peer Reviewed
• [Journal Article] Immediate breast reconstruction using autologous free dermal fat grafts provides better cosmetic results for patients with upper inner cancerous lesions (2011)
  • Author(s): Kijima Y, Yoshinaka H, Funasako Y, Kaneko K, Hirata M, Mizoguchi T, Ishigami S, Arima H, Nakajo A, Ueno S, Natsugoe S.
  • Journal Title: Surg Today Volume: 41(4) Pages: 477-89
  • Peer Reviewed
• [Journal Article] Prognostic impact of CD168 expression in gastric cancer (2011)
  • Author(s): Ishigami S, Ueno S, Nishizono Y, Matsumoto M, Kurahara H, Arigami T Uchikado Y, Setoyama T, Arima H, Yoshiaki K, Kijima Y, Kitazono M, Natsugoe S.
  • Journal Title: BMC Cancer Volume: 11 Pages: 106
  • Peer Reviewed
• [Journal Article] Postoperative long-term evaluation of interposition reconstruction compared with Roux-en-Y after total gastrectomy in gastric cancer : prospective randomized controlled trial (2011)
  • Author(s): Ishigami S, Natsugoe S, Hokita S, Aoki T, Kashiwagi H, Hirakawa K, Sawada T, Yamamura Y, Itoh S, Hirata K, Ohta K, Mafune K, Nakane Y, Kanda T, Furukawa H, Sasaki I, Kubota T, Kitajima M, Aikou T.
  • Journal Title: Am J Surg Volume: 202(3) Pages: 247-53
  • Peer Reviewed
• [Journal Article] Clinical implication of HLA class I expression in breast cancer (2011)
  • Author(s): Kaneko K, Ishigami S, Kijima Y, Funasako Y, Hirata M, Okumura H, Shinchi H, Koriyama C, Ueno S, Yoshinaka H, Natsugoe S.
  • Journal Title: BMC Cancer Volume: 11 Pages: 454
  • Peer Reviewed
• [Journal Article] Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis (2010)
  • Author(s): Arigami T, Uenosono Y, Hirata M, Hagihara T, Yanagita S, Ishigami S, Natsugoe S.
  • Journal Title: J Surg Oncol Volume: 102(7) Pages: 748-52
  • Peer Reviewed
• [Journal Article] Prognostic value of CD208-positive cell infiltration in gastric cancer (2010)
  • Author(s): Ishigami S, Ueno S, Matsumoto M, Okumura H, Arigami T, Uchikado Y, Setoyama T, Arima H, Sasaki K, Kitazono M, Shinchi H, Kijima Y, Natsugoe S.
  • Journal Title: Cancer Immunol Immunother Volume: 59 Pages: 389-95
  • Peer Reviewed
• [Journal Article] Prognostic impact of CD133 expression in gastric carcinoma (2010)
  • Author(s): Ishigami S Ueno S, Arigami T, Uchikado Y, Setoyama T, Arima H, Kita Y, Kurahara H, Okumura H, Matsumoto M, Kijima Y, Natsugoe S.
  • Journal Title: Anticancer Res Pages: 2453-57
  • Peer Reviewed
• [Journal Article] Roux-en-Y reconstruction with stapled distal jejunal pouch after total gastrectomy 2010 Am Surg 76 (2010)
  • Author(s): Ishigami S Aridome K, Nakajo A, Matsumoto M, Uchikado Y, Setoyama T, Arigami T, Arima H, Ueno S, Kijima Y, Aikou T, Natsugoe S.
  • Volume: 76
  • Pages: 526-528
  • Peer Reviewed
• [Journal Article] Nuclear expression of 14-3-3 sigma is related to prognosis in patients with esophageal squamous cell carcinoma (2010)
  • Author(s): Okumura H, Kita Y, Yokomakura N, Uchikado Y, Setoyama T, Sakurai H, Omoto I, Matsumoto M, Owaki T, Ishigami S, Natsugoe S.
  • Journal Title: Anticancer Res Volume: 30 Pages: 5175-9
  • Peer Reviewed
• [Journal Article] Oncoplastic surgery in a Japanese patient with breast cancer in the lower inner quadrant area : partial mastectomy using horizontal reduction mammoplasty (2010)
  • Author(s): Kijima Y, Yoshinaka H, Hirata M, Mizoguchi T, Ishigami S, Nakajo A, Arima H, Ueno S, Natsugoe S.
  • Journal Title: Breast Cancer
  • Peer Reviewed
• [Journal Article] ESD時代の外科治療 (2010)
  • Author(s): 石神純也
  • Journal Title: 臨床外科 Volume: 65 Pages: 1108-1111
  • Peer Reviewed
• [Presentation] 胃全摘後RouX-Y法Y脚部パウチ再建法 (2010)
  • Author(s): 石神純也
  • Organizer: 第72回日本臨床外科学会総会
  • Place of Presentation: 名古屋市愛知県
  • Year and Date: 20101121-23
• [Presentation] 高度進行胃癌に対する審査腹腔鏡の診断成績 (2010)
  • Author(s): 石神純也
  • Organizer: 第23回日本内視鏡外科学会総会
  • Place of Presentation: 横浜市神奈川県
  • Year and Date: 2010-10-18
• [Presentation] Therapeutic strategy in esophagogastric junction cancer (2010)
  • Author(s): 石神純也
  • Organizer: 9^<th> International Conference of the Asian Clinical Oncology Society
  • Place of Presentation: 岐阜市岐阜県
  • Year and Date: 2010-08-26
• [Presentation] 高度進行胃癌に対する化療後の追加外科手術の有用性について (2010)
  • Author(s): 石神純也
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 下関市山口県
  • Year and Date: 2010-07-14
• [Presentation] Salvage surgery following chemotherapy for stage IV gastric cancer (2010)
  • Author(s): 石神純也
  • Organizer: The 17th Czech-Japan Surgical Symposium
  • Place of Presentation: 金沢市石川県
  • Year and Date: 2010-06-06
• [Presentation] StageIV進行胃癌に対する化療後のR0手術の有用性 (2010)
  • Author(s): 石神純也
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋市愛知県
  • Year and Date: 2010-04-08