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2011 Fiscal Year Final Research Report

A novel therapeutic strategy for colorectal cancer using stromal cells

Research Project

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Project/Area Number 21591708
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionSapporo Medical University

Principal Investigator

FURUHATA Tomohisa  札幌医科大学, 医学部, 准教授 (80359992)

Co-Investigator(Kenkyū-buntansha) NISHIDATE Toshihiko  札幌医科大学, 医学部, 助教 (80404606)
KIMURA Yasutoshi  札幌医科大学, 医学部, 講師 (80311893)
OKITA Kenji   (70517911)
Project Period (FY) 2009 – 2011
Keywords大腸癌 / VEGF-A / マクロファージ / 線維芽細胞
Research Abstract

VEGF-A expression in stromal tissue is thought to be a better prognostic factor and VEGF165b, which is mainly expressed in stromal tissue, inhibits the angiogenesis in colorectal cancer

  • Research Products

    (8 results)

All 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results)

  • [Journal Article] Vascular endothelial growth factor 165b expression in stromal cells and colorectal cancer2011

    • Author(s)
      Tayama M, Furuhata T, Inafuku Y, Okita K, Nishidate T, Mizuguchi T, Kimura Y, Hirata K
    • Journal Title

      World J Gastroenterol

      Volume: 17(44) Pages: 4867-74

    • Peer Reviewed
  • [Journal Article] Phase II study of S-1 plus leucovorin in patients with metastatic colorectal cancer2010

    • Author(s)
      Koizumi W, Boku N, Yamaguchi K, Miyata Y, Sawaki A, Kato T, Toh Y, Hyodo I, Nishina T, Furuhata T, Miyashita K, Okada Y
    • Journal Title

      Ann Oncol

      Volume: 21(4) Pages: 766-71

    • Peer Reviewed
  • [Journal Article] Effects of a low-fat meal on the oral bioavailability of UFT and leucovorin in patients with colorectal cancer2009

    • Author(s)
      Furuhata T, Meguro M, Nishidate T, Okita K, Ishiyama G, Iwayama Y, Hosokawa Y, Tsuruma T, Kimura Y, Mizuguchi T, Sasaki K.
    • Journal Title

      Int J Clin Oncol

      Volume: 14(6) Pages: 529-33

    • Peer Reviewed
  • [Journal Article] Clinical compliance with an oral uracil/tegafur(UFT) plus leucovorin(LV) regimen as adjuvant chemotherapy in Japanese colorectal cancer patients2009

    • Author(s)
      Meguro M, Furuhata T, Okita K, Nishidate T, Ishiyama G, Iwayama Y, Kimura Y, Mizuguchi T, Hirata K
    • Journal Title

      Int J Clin Oncol

      Volume: 14(5) Pages: 402-7

    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase-2 expression in stromal tissues is a consistent prognostic factor in stage II colon cancer2009

    • Author(s)
      Inafuku Y, Furuhata T, Tayama M, Okita K, Nishidate T, Mizuguchi T, Kimura Y, Hirata K
    • Journal Title

      Cancer Sci

      Volume: 100(5) Pages: 852-8

    • Peer Reviewed
  • [Presentation] MMP-2発現解析によるStgae2結腸癌の悪性度診断2010

    • Author(s)
      田山誠、古畑智久
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      下関
    • Year and Date
      2010-07-15
  • [Presentation] 大腸癌におけるVEGF165b発現解析の臨床的意義2010

    • Author(s)
      古畑智久
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-10
  • [Presentation] Matrix metalloproteinase 2 expression in stromal tissues is a consistent prognostic factor in Stage II colon cancer2009

    • Author(s)
      Furuhata T
    • Organizer
      International Surgical Week 2009
    • Place of Presentation
      Adelaide, Australia
    • Year and Date
      2009-09-07

URL: 

Published: 2013-07-31  

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