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2011 Fiscal Year Final Research Report

Molecular analysis of SnoN and microRNA in esophageal squamous cell carcinoma

Research Project

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Project/Area Number 21591714
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionNippon Medical School

Principal Investigator

MIYASHITA Masao  日本医科大学, 医学部, 教授 (70229847)

Co-Investigator(Kenkyū-buntansha) TAKIZAWA Toshihiro  日本医科大学, 大学院・医学研究科, 教授 (90271220)
ISHIBASHI Osamu  日本医科大学, 医学部, 護師 (70293214)
MAKINO Kouji  日本医科大学, 医学部, 准教授 (30267207)
NOMURA Tsutomu  日本医科大学, 医学部, 准教授 (60287737)
HAGIWARA Nobutoshi  日本医科大学, 医学部, 助教 (00328824)
Co-Investigator(Renkei-kenkyūsha) AKAGI Ichiro  日本医科大学, 医学部, 助教 (90552662)
Project Period (FY) 2009 – 2011
Keywords食道外科学
Research Abstract

The target miRNAs for SnoN were investigated in esophageal cancer. Using human esophageal cancer cell lines, SnoN expression was inhibited using siRNA, and altered miRNAs were identified as miR-720, miR-1274A, miR-1274B with p63 and ADAM9 as the possible relevant genes. The induction of SnoN expression was positively correlated to miRNA expression. However, the effect of SnoN expression on cell growth is still unclear and needs further investigation.

  • Research Products

    (2 results)

All 2011 2010

All Journal Article (1 results) Presentation (1 results)

  • [Journal Article] Relationship between altered expression levels of MIR21, MIR143, and MIR205 and clinicopathologic features of esophageal squamous cell carcinoma2011

    • Author(s)
      Akagi I, Miyashita M, Ishibashi O, Mishima T, Makino H, Nomu Uchida E, Takizawa T.
    • Journal Title

      Dis Esophagus

      Volume: 24(7) Pages: 523-530

    • DOI

      doi:10.1111/j.1442-2050.2011.01177.x.

  • [Presentation] 食道扁平上皮癌におけるMIR21, MIR143 MIR145, MIR205の発現の意義2010

    • Author(s)
      萩原信敏、宮下正夫, 他8名
    • Organizer
      第110回日本外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-08

URL: 

Published: 2013-07-31  

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