2011 Fiscal Year Final Research Report
Mechanism of drug resistance by Epithelial-Mesenchymal Transition and bone marrow stem cell
| Project/Area Number |
21591720
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Gunma University |
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Principal Investigator |
TSUTSUMI Soichi 群馬大学, 大学院・医学系研究科, 助教 (30323356)
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| Co-Investigator(Kenkyū-buntansha) |
ASAO Takayuki 群馬大学, 大学院・医学系研究科, 准教授 (40212469)
FUJII Takaaki 群馬大学, 医学部, 助教 (40507331)
KUWANO Hiroyuki 群馬大学, 大学院・医学系研究科, 教授 (90186560)
KOSAKA Takayuki 群馬大学, 医学部, 助教 (00507329)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 上皮間葉移行 / 抗癌剤耐性 / 骨髄幹細胞 |
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| Research Abstract |
The epithelial to mesenchymal transition(EMT)is a molecular process through which an epithelial cell undergoes differentiation into a mesenchymal phenotype. The relationship between EMT and resistance to an anti-cancer drug in colorectal cancer remains unknown. In this study, we investigated the acquisition of EMT by 5-FU in colorectal cell lines. 5-FU resistant cell lines did not change into a mesenchymal phenotype. This study suggests that EMT phenotype may not play a significant role in anti-cancer agent resistance in colorectal cancer
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[Presentation] 一般口演大腸癌に対するBevacizumab治療継続の有効性・安全性の検討第II相試験SILK Study【中間報告】2010
Author(s)
堤荘一, 石橋敬一郎, 木暮和夏子, 平山功, 片山和久, 内田信行, 保田尚邦, 細内康男, 根岸健, 浅尾高行, 西田保二, 石田秀行, 桑野博行
Organizer
第48回日本癌治療学会学術集会
Place of Presentation
京都
Year and Date
20101028-30
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