2011 Fiscal Year Final Research Report
Molecular mechanism of hypoxia-induced genome instability in human colorectal cancer
| Project/Area Number |
21591736
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIBUYA Kazutoshi 東邦大学, 医学部, 教授 (20196447)
ARITA Michitsune 東邦大学, 医学部, 助教 (80307719)
KOIKE Junichi 東邦大学, 医学部, 講師 (30339155)
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| Co-Investigator(Renkei-kenkyūsha) |
KANAZAWA Shinsaku 東邦大学, 医学部, 助教 (00408767)
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| Research Collaborator |
LI Jie 東邦大学, 医学部, 大学院生
YAMADA Kanae 東邦大学, 医学部, 研究生
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| Project Period (FY) |
2009 – 2011
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| Keywords | 遺伝子 / 大腸がん / ゲノム不安定性 / EMAST / 発現制御 / 低酸素 / DNA修復 |
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| Research Abstract |
Frequency of EMAST, a phenotype of genetic instability, in Japan was approximately 60%, which is similar to USA. Down-regulation of hMSH3 by hypoxia was studied in human cell lines derived from different origins including colon. Three patterns : rapid, moderate, and none responses were observed. Moderate type was observed in cells having mutant p53.Histochemical staining of clinical samples supports that down-regulation of hMSH3 is induced by hypoxia. Transient hypoxia is not enough for generation of EMAST tumor. Repeated states of hypoxia-reoxyganation may require for induction of EMAST.
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[Journal Article] 14-3-3σ-dependent resistance to cisplatin2009
Author(s)
Han Z, Dimas K, Tian X, Wang Y, Hemmi H, Yamada K, Kato N, Pantazis P, Ramanujam RJ, Anant S, Wyche JH, Houchen CW
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Journal Title
Anticancer Res
Volume: 29(6)
Pages: 2009-2014
Peer Reviewed
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