Evaluation of the signal transduction that controls hepatic sinusoidal regeneration and attempt to promote liver regeneration using endothelial progenitor cells.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591744
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Chiba University
• Principal Investigator: SHIMIZU Hiroaki 千葉大学, 大学院・医学研究院, 講師 (80272318)
• Co-Investigator(Kenkyū-buntansha): MIYAZAKI Masaru 千葉大学, 大学院・医学研究院, 教授 (70166156) ; KIMURA Fumio 千葉大学, 大学院・医学研究院, 准教授 (70334208) ; OHTSUKA Masayuki 千葉大学, 医学部附属病院, 講師 (90334185)
• Project Period (FY): 2009 – 2011
• Keywords: 肝再生 / 類洞内皮細胞 / 血管内皮前駆細胞 / 肝切除

Research Abstract

VEGF secreted by hepatocytes may play a key role in SEC proliferation, followed by increased Ang-1, presumably promoting sinusoidal maturation. Thereafter, Ang-2 mainly released from HSCs in the absence of VEGF may contribute to apoptosis of superfluous SECs for cessation of the regenerative process. In conclusion, Ang-Tie system, together with VEGF plays a critical role in regulating balance between SEC proliferation and apoptosis during sinusoidal regeneration after hepatectomy

Research Products

• [Journal Article] Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma (2012)
  • Author(s): Miura S, Mitsuhashi N, Shimizu H, Kimura F, Yoshidome H, Ohtsuka M, Kato A, Shida T, Okamura D, Miyazaki M
  • Journal Title: BMC Cancer Volume: 12 Pages: 56-70
  • Peer Reviewed
• [Journal Article] Effect of excessive acute-phase response on liver regeneration after partial hepatectomy in rats (2009)
  • Author(s): Kusashio K, Shimizu H, Kimura F, Yoshidome H., Ohtsuka M, Kato, A., Yoshitomi, H., Furukawa, K., Fukada, T, Miyazaki M
  • Journal Title: Hepatogastroenterology Volume: 56 Pages: 824-828
  • Peer Reviewed
• [Journal Article] Role of Kupffer cells in tolerance induction after portal venous administration of alloantigen (2009)
  • Author(s): Shimizu H, Kataoka M, Kimura F, Yoshidome H, Ohtsuka M, Kato A, Miyazaki M
  • Journal Title: Hepatogastroenterology Volume: 56 Pages: 783-787
  • Peer Reviewed
• [Journal Article] Induction of antitumor response by in vivo allogeneic major histocompatibility complex gene transfer using electroporation (2009)
  • Author(s): Shimizu H, Nukui Y, Mitsuhashi N, Kimura F, Yoshidome H, Ohtsuka M, Kato A, Miyazaki M
  • Journal Title: J Surg Res Volume: 154 Pages: 60-67
  • Peer Reviewed
• [Remarks]
  • URL: http://dx.doi.org/10.1016/j.jss.2008.05.035