2011 Fiscal Year Final Research Report
Investigation of relationship between the liver and spleen via the portal circulation in sepsis
| Project/Area Number |
21591745
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Yamanashi |
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Principal Investigator |
KONO Hiroshi 山梨大学, 大学院・医学工学総合研究部, 助教 (40322127)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Masanori 山梨大学, 医学部附属病院, 講師 (80242642)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腹膜炎 / 自然免疫 / マクロファージ / 膵臓 / 臓器相関 |
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| Research Abstract |
The purpose of this study was to investigate whether inhibition of Kupffer cells(KCs) affects the expression of HMGB1 and mortality in septic peritonitis. Furthermore, the role of the spleen in septic peritonitis was also investigated. Elimination of the Kupffer cells increased mortality significantly. Furthermore, on the other hand, splenectomy improved mortality in animals with or without KC inhibition after CLP. Thus, the liver and spleen play key roles in host defense during septic peritonitis.
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