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2011 Fiscal Year Final Research Report

Significance of serum bile acid level to predict the effective functional hypertrophy of the nonembolized liver after portal vein embolization

Research Project

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Project/Area Number 21591757
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKumamoto University

Principal Investigator

BEPPU Toru  熊本大学, 医学部附属病院, 准教授 (70301372)

Co-Investigator(Kenkyū-buntansha) HORINO Kei  熊本大学, 医学部附属病院, 非常勤診療医師 (60452900)
BABA Hideo  熊本大学, 大学院・生命科学研究部, 教授 (20240905)
Project Period (FY) 2009 – 2011
Keywords増殖因子 / 肝再生 / 肝細胞増殖因子(HGF) / 肝萎縮 / 胆汁酸 / 門脈塞栓術 / 肝切除
Research Abstract

The clinical association between serum bile acid level changes and liver hypertrophy in portal vein embolization(PVE) is unknown. We clarified that PVE increases the serum bile acid level in patients with effective liver hypertrophy and the increase on day 3 is a useful predictor of effective hypertrophy(r=0. 613、P=0. 002). Serum bile acid levels were significantly higher in non-external bile drainage group and the regenerated liver volume was significantly greater(129ml vs. 39ml, P<0. 05). Besides, serum bile acid level is a useful predictor of liver regeneration.

  • Research Products

    (12 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (5 results)

  • [Journal Article] Portal vein embolization can prevent intrahepatic metastases to non-embolized liver2012

    • Author(s)
      Okabe K, Beppu T, Masuda T, Hayashi H, Okabe H, Komori H, Horino K, Sugiyama S, Ishiko T, Takamori H, Yamanaka T, Baba H
    • Journal Title

      Hepato-Gastroenterol

      Volume: 59 Pages: 538-41

    • Peer Reviewed
  • [Journal Article] Liver Functional Volumetry for Portal Vein Embolization Using a Newly-Developed 99mTc-Galactosyl Human Serum Albumin Scintigraphy SPECT-Computed Tomography Fusion System2011

    • Author(s)
      Beppu T, Hayashi H, Okabe H, Masuda T, Mima K, Sugiyama S, Horino K, Otao R, Chikamoto A, Doi K, Ishiko T, Takamori H, Yoshida M, Shiraishi S, Yamashita Y, Baba H
    • Journal Title

      J Gastroenterol

      Volume: 46(7) Pages: 938-43

    • Peer Reviewed
  • [Journal Article] Preoperative portal vein embolization(PVE) for patients with hepatocellular carcinoma can improve resectability and may improve disease-free survival2011

    • Author(s)
      Okabe H, Beppu T, Ishiko T, Masuda T, Hasyashi H, Otao R, Hasta H, Okabe K, Sugiyama S, Baba H
    • Journal Title

      J Surg Oncol

      Volume: 104(6) Pages: 641-6

    • Peer Reviewed
  • [Journal Article] A new approach to percutaneous transhepatic portal embolization using ethanolamine oleate iopamidol2010

    • Author(s)
      Beppu T, Iwatsuki M, Okabe H, Okabe K, Masuda T, Hayashi H, Sugiyama S, Horino K, Komori H, Hayashi N, Takamori H, Ishiko T, Baba H
    • Journal Title

      J Gastroenterol

      Volume: 45 Pages: 211-217

    • Peer Reviewed
  • [Journal Article] Serum HGF and TGF-b1 levels after right portal vein embolization2010

    • Author(s)
      Hayashi H, Beppu T, Sugita H, Horino K, Masuda T, Okabe H, Takamori H, Baba H
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 311-317

    • Peer Reviewed
  • [Journal Article] アシアロSPECT/CT融合画像による分肝機能評価2010

    • Author(s)
      別府透、林洋光、岡部弘尚、増田稔郎、太田尾龍、近本亮、石河隆敏、高森啓史、馬場秀夫白石慎哉、吉田守克、山下康行
    • Journal Title

      消化器内科

      Volume: 50 Pages: 443-446

  • [Journal Article] Increase in the serum bile acid level predicts the effective hypertrophy of the nonembolized hepatic lobe after right portal vein embolization2009

    • Author(s)
      Hayashi H, Beppu T, Sugita H, Horino K, Komori H, Masuda T, Okabe H, Takamori H, Baba H
    • Journal Title

      World J Surg

      Volume: 33 Pages: 1933-40

    • Peer Reviewed
  • [Presentation] Preoperative portal vein embolization(PVE) can improve disease-free survival for patients with hepatocellular carcinoma2011

    • Author(s)
      Toru Beppu, Hideo Baba, et al.
    • Organizer
      International Surgical Week 2011
    • Place of Presentation
      Pacifico Yokohama, Japan
    • Year and Date
      2011-08-31
  • [Presentation] 肝切除後の肝再生予測因子としての血清胆汁酸測定の意義2010

    • Author(s)
      太田尾龍、別府透、馬場秀夫, 他
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      海峡メッセ下関、下関市民会館(山口)
    • Year and Date
      2010-07-14
  • [Presentation] 門脈塞栓術前後における血清HGF, TGF-beta1の推移の臨床的意義2009

    • Author(s)
      林洋光、別府透、馬場秀夫, 他
    • Organizer
      第64回日本消化器外科学会総会
    • Place of Presentation
      大阪,大阪国際会議場
    • Year and Date
      2009-07-17
  • [Presentation] 右門脈塞栓術後の血清胆汁酸濃度のモニタリングは左葉の肝再生の予測に有用である2009

    • Author(s)
      林洋光、別府透、馬場秀夫, 他
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      兵庫神戸ポートピアホテル
    • Year and Date
      2009-06-04
  • [Presentation] 肝切除後における胆汁外瘻化が肝再生を阻害する2009

    • Author(s)
      太田尾龍、別府透、馬場秀夫, 他
    • Organizer
      第109回日本外科学会
    • Place of Presentation
      福岡、福岡国際会議場
    • Year and Date
      2009-04-04

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Published: 2013-07-31  

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