2011 Fiscal Year Final Research Report
Liver repair and reconstitution of the hepatic sinusoids after acute liver injury
| Project/Area Number |
21591761
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kitasato University |
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Principal Investigator |
ITOH Yoshiya 北里大学, 医学部, 非常勤講師 (40203187)
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| Co-Investigator(Kenkyū-buntansha) |
MAJIMA Masataka 北里大学, 医学部, 教授 (70181641)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肝再生 |
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| Research Abstract |
The failure of liver to regenerate is considered a critical contributing factor in liver dysfunction and liver failure after chemical, liver surgery, and inflammation. Hepatic tissue repair, including the reconstitution of hepatic microvasculature, plays a critical role in determining the final outcome of acutely injured liver. The present study was conducted to examine whether VEGF, a well-known angiogenic growth factor, and its receptor, VEGFR1, are involved in liver repair and regeneration. In the model of acute liver injury elicited by acetaminophen(APAP) and hepatic ischemia/reperfusion, VEGFR1 signaling plays an important role in liver repair and sinusoidal restoration after APAP hepatotoxicity and hepatic ischemia/reperfusion through the recruitment of macrophages expressing VEGFR1.
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Author(s)
Mishima T, Ito Y, Hosono K, Tamura Y, Uchida Y, Hirata M, Suzuki T, Amano H, Kato S, Kurihara Y, Kurihara H, Hayashi I, Watanabe M, Majima M.
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Journal Title
Am J Physiol Heart Circ Physiol
Volume: 300(2)
Pages: H431-H439
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[Journal Article] COX-2 and Prostaglandin EP3/EP4 Signaling Regulate the Tumor Stromal Proangiogenic Microenvironment via CXCL12-CXCR4 Chemokine Systems2010
Author(s)
Katoh H, Hosono K, Ito Y, Suzuki T, Ogawa Y, Kubo H, Kamata H, Mishima T, Tamaki H, Sakagami H, Sugimoto Y, Narumiya S, Watanabe M, Majima M.
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Journal Title
Am J Pathol
Volume: 176(3)
Pages: 1469-83
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[Journal Article] Bone marrow-derived EP-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth2009
Author(s)
Ogawa Y, Suzuki T, Oikawa A, Hosono K, Kubo H, Amano H, Ito Y, Kitasato H, Hayashi I, Kato T, Sugimoto Y, Narumiya S, Watanabe M, Majima M.
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Journal Title
Biochem Biophys Res Commun
Volume: 382(4)
Pages: 720-725
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