2011 Fiscal Year Final Research Report
Angiogenesis and lymphagenesis targeted molecular therapy for cholangiocarcinoma.
| Project/Area Number |
21591765
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UYAMA Naoki 兵庫医科大学, 医学部, 研究生(研究員) (70402873)
SATAKE Makoto 兵庫医科大学, 医学部, 助教 (70399153)
IIMURO Yuuji 兵庫医科大学, 医学部, 教授 (30252018)
FUJIMOTO Jiro 兵庫医科大学, 医学部, 教授 (90199373)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肝臓外科学 |
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| Research Abstract |
In the present study, we investigated the role of CXCR2 in intrahepatic cholangiocellular carcinoma(ICC). First, expression of CXCR2 is estimated by immunohistochemical staining in ICC using thirty ICC human specimens. Next, the role of CXCR2 was estimated in vitro by proliferation assay, migration assay, or invasion assay. In vivo effect was also estimated using xenograft mice model. As a result, blockage of CXCR2 significantly inhibited proliferation, migration, and invasion of ICC in vitro. Tumor growth of xenograft mice model was also inhibited by CXCR2 antagonist. Our results suggested that CXCR2 act crucial role in the development of ICC. Blockage of CXCR2 may be a promising therapeutic approach for ICC.
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