2011 Fiscal Year Final Research Report
Mode of Hepatic Spread from Gallbladder Carcinoma : An Immunohistochemical Analysis of 42 Hepatectomized Specimens
| Project/Area Number |
21591769
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Niigata University |
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Principal Investigator |
SHIRAI Yoshio 新潟大学, 医歯学系, 准教授 (50216173)
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| Co-Investigator(Kenkyū-buntansha) |
WAKAI Toshifumi 新潟大学, 医歯学総合病院, 講師 (50372470)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 胆道外科学 / 胆嚢癌 / 肝内進展様式 / リンパ管侵襲 / 静脈侵襲 / モノクローナル抗体 / 肝切除術 / 癌の転移 |
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| Research Abstract |
In the current study, we analyzed the mode of hepatic spread from gallbladder carcinoma by examining immunohistochemically the resected specimens taken from 52 patients with hepatic spread. In summary, direct liver invasion and portal tract invasion, which featured intrahepatic lymphatic invasion, were the main modes of hepatic spread from resectable disease. The mode of hepatic spread independently predicted long-term survival after resection for patients with gallbladder carcinoma. Hepatic metastatic nodules indicated a dismal outcome after resection.
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