2011 Fiscal Year Final Research Report
Tailor-made therapy for cancer based on tumor angiogenesis and hypoxia
| Project/Area Number |
21591772
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
MORI Akira 京都大学, 医学研究科, 非常勤講師 (60324646)
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| Co-Investigator(Kenkyū-buntansha) |
HATA Koichiro 京都大学, 医学研究科, 助教 (90523118)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腫瘍血管新生 / 低酸素 / 分子標的治療 / 膵癌 / 肝細胞癌 / 肝移植 |
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| Research Abstract |
Kruppel-like factor 5(KLF5) is a transcription factor involved in cell transformation, proliferation, and carcinogenesis that can be up-regulated by RAS mutations. However, controversy persists as to whether it functions as a tumor suppressor or as an oncogene. The overexpression of KLF5 in human pancreatic cancer cells is not mediated by KRAS/Raf/MAPK/Erk signaling, but involves the IL-1beta/IL-1R system, p38, and the transcription factor HIF-1alpha. KLF5 is a promising candidate of target molecule in pancreatic cancer therapy. We are now investigating the clinical significance of KLF5 in pancreatic cancer patients.
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