2011 Fiscal Year Final Research Report
Profiling and functional analyses of microRNAs in human intrahepatic cholangiocarcinoma
| Project/Area Number |
21591784
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Hiroshi 日本医科大学, 医学部, 准教授 (60246999)
KIKUCHI Kunio 日本医科大学, 医学部, 講師 (70374676)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 外科学 / 胆道 / 癌 / microRNA |
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| Research Abstract |
We examined functional analysis of biliary epithelial cell-specific miRNAs in a human intrahepatic cholangiocarcinoma cell line(HuCCT1). We identified a growth factor receptor binding protein(GRB), which is implicated in tyrosine kinase signal transduction, as a biliary epithelial cell-specific miRNA target. It is likely that upregulation of the GRB protein by downregulation of the biliary epithelial cell-specific miRNAs contributes to motility in HuCCT1.
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