2011 Fiscal Year Final Research Report
A novel approach to treat acute respiratory failure by combination of type 2 alveolar epithelial regeneration and alveolar macrophage inhibition
| Project/Area Number |
21591810
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHINOHARA Hirohiko 新潟大学, 医歯学系, 助教
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肺障害 / 気道上皮再生 / サイトカイン |
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| Research Abstract |
In vitro cell culture experiment demonstrated that airway epithelial cell growth was improved by adding cytokines in the culture medium. Erectroporation also improved efficacy of gene introduction into culture cells of airway epithelium. Gene expression was observed in the alveolar epithelium by intratracheal administration of naked gene. However, lung injury due to pressure to epithelium was observed.
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