Computed Simulation System for Cryoablation Therapy of Lung Tumor

2011 Fiscal Year Final Research Report

• Project/Area Number: 21591823
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Teikyo University (2010-2011); Keio University (2009)
• Principal Investigator: KAWAMURA Masafumi 帝京大学, 医学部, 教授 (70169770)
• Co-Investigator(Kenkyū-buntansha): IZUMI Yotaro 慶應義塾大学, 医学部, 専任講師 (90245506) ; ASAKURA Keisuke 慶應義塾大学, 医学部, 助教 (90383786) ; YAMAUTI Yosikane 慶應義塾大学, 医学部, 助教 (30445390) ; HASHIMOTO Kohei 慶應義塾大学, 医学部, 助教 (70464964)
• Project Period (FY): 2009 – 2011
• Keywords: 凍結療法 / 肺がん / 転移性肺腫瘍 / 癌の低侵襲治療 / コンピュータシミュレーション / 3次元モデル

Research Abstract

With thermal monitoring of porcine lung treated by cryoablation, sequential spread of low temperature zone around cryoprobe in the porcine lung could be imaged theoretically. Then correlation between CT findings and pathological feature after lung cryoablation and low temperature zone(less than-20℃) during cryoablation was evaluated. These data should make possible to construct computed simulation system for optimal insertion of cryoprobe in the lung.

Research Products

• [Journal Article] Prediction of the critical thermalzone during pulmonary cryoablation on computed tomography from correlated experimental and clinical findings (2012)
  • Author(s): Hashimoto K, Izumi Y, Yamauchi Y, Yashiro H, Inoue M, Nakatsuka S, et al.
  • Journal Title: J Thorac Cardiovasc Surg Pages: e1-7
  • Peer Reviewed
• [Journal Article] Nomori H Percutaneous cryoablation for the treatment of medically inoperable stage I non-small cell lung cancer (2012)
  • Author(s): Yamauchi Y, Izumi Y, Hashimoto K, Yashiro H, Inoue M, Nakatsuka S, Goto T, Anraku M, Ohtsuka T, Kohno M, Kawamura M
  • Journal Title: PloS One Volume: 7 Pages: e33223
  • Peer Reviewed
• [Journal Article] Percutaneous cryoablation of lung tumors : feasibility and safety (2012)
  • Author(s): Inoue M, Nakatsuka S, Yashiro H, Ito N, Izumi Y, Yamauchi Y, Hashimoto K, Asakura K, Tsukada N, Kawamura M, Nomori H, Kuribayashi S
  • Journal Title: J Vasc Interv Radiol Volume: 23 Pages: 295-302
  • Peer Reviewed
• [Journal Article] Percutaneous cryoablation for pulmonary nodules in the residual lung after pneumonectomy : report of two cases (2011)
  • Author(s): Yamauchi Y, Izumi Y, Yashiro H, Inoue M, Nakatsuka S, Kawamura M, Nomori H
  • Journal Title: Chest Volume: 140 Pages: 1633-7
  • Peer Reviewed
• [Journal Article] Percutaneous cryoablation of pulmonary metatsases from colorectal cancer (2011)
  • Author(s): Yamauchi Y, Izumi Y, Kawamura M, Nakatsuka S, Yashiro H, Tsukada N, Inoue M, Asakura K, Nomori H
  • Journal Title: PloS One Volume: 6 Pages: e27086
  • Peer Reviewed
• [Journal Article] On freeze-thaw sequence of vital organ of assuming the cryoablation for malignant lung tumors by using cryoprobe as heat source (2010)
  • Author(s): Nakatsuka S, Yashiro H, Inoue M, Kuribayashi S, Kawamura M, Izumi Y, Tsukada N, Yamauchi Y, Hashimoto K, et al.
  • Journal Title: Cryobiology Volume: 61 Pages: 317-26
  • Peer Reviewed
• [Journal Article] 転移性肺腫瘍治療のパラダイムシフト (2010)
  • Author(s): 川村雅文
  • Journal Title: 日本胸部臨床2010 Volume: 69 Pages: S169-75
• [Presentation] The result of percutaneous cryoablation for resectable primary lung cancer (2010)
  • Author(s): Yamauchi Y
  • Organizer: 35th European Society for Medical Oncology
  • Place of Presentation: Milan, Italy
  • Year and Date: 20101000