2011 Fiscal Year Final Research Report
Identification of a tumor associated antigen in lung cancer patients with asbestos exposure and its potential for diagnosis application
| Project/Area Number |
21591830
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
YASUDA Manabu 産業医科大学, 医学部, 非常勤医師 (50352307)
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| Co-Investigator(Kenkyū-buntansha) |
HANAGIRI Takeshi 産業医科大学, 医学部, 准教授 (30299614)
TAKENOYAMA Mituhiro 産業医科大学, 医学部, 非常勤講師 (10309966)
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| Project Period (FY) |
2009 – 2011
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| Keywords | アスベスト / 肺癌 / 腫瘍抗原 / Annexin A2 / SEREX |
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| Research Abstract |
This study analysed the humoral immune response in lung cancer patients with asbestos exposure in order to identify new surrogate markers of the carcinogenic risk in populations exposed to asbestos. A serological analysis identified five distinct antigens reactive with IgG derived from a lung cancer patient with high asbestos exposure. In one of the isolated antigens, quantitative RT-PCR indicated that annexin A2(AnxA2) was overexpressed in lung cancer tissues and normal lung from patients with high asbestos exposure. Antibody against AnxA2 was detected in 9/15(60%) of lung cancer patients with high asbestos exposure ; however, in only 1/12(8%) of lung cancer patients with low asbestos exposure. AnxA2 was also overexpressed in malignant mesothelioma cells, and the antibody was also positive in 9/15(60%) of patients with malignant mesothelioma. Furthermore, this study also focused on the clinical significance of pre-operative serum levels of Osteopontin(OPN) in patients with NSCLC who underwent a complete resection. The pre-operative serum OPN level of each patient was a useful predictor of an unfavorable prognosis, however, it was not associated with previous asbestos exposure. In conclusion, the antibody titer against AnxA2 may be a potentially useful new diagnostic surrogate marker for asbestos-related lung cancer and malignant mesothelioma.
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[Journal Article] Identification of a tumour associated antigen in lung cancer patients with asbestos exposure2010
Author(s)
Yasuda M, Hanagiri T, Shigematsu Y, Onitsuka T, Kuroda K, Baba T, Mizukami M, Ichiki Y, Uramoto H, Takenoyama M, Yasumoto K
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Journal Title
Anticancer Res
Volume: 30
Pages: 2631-2639
Peer Reviewed
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[Presentation] pN2-III期非小細胞肺癌に対する外科切除例の検討2011
Author(s)
竹中賢, 中川誠, 篠原伸二, 〓田泰治, 岡壮一, 近石泰弘, 重松義紀, 永田好香, 下川秀彦, 浦本秀隆, 宗知子, 花桐武志, 田中文啓
Organizer
第52回日本肺癌学会総会
Place of Presentation
大阪国際会議場大阪
Year and Date
20111103-04
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[Presentation] 石綿関連悪性腫瘍(胸膜中皮腫、肺癌)に対する新規バイオマーカー2009
Author(s)
安田学, 花桐武志, 重松義紀, 黒田耕志, 鬼塚貴光, 馬場哲郎, 宗哲哉, 小野憲司, 浦本秀隆, 宗知子, 竹之山光広, 安元公正
Organizer
第63回日本呼吸器学会・日本結核病学会九州支部秋季学術講演会
Place of Presentation
北九州国際会議場北九州
Year and Date
20091126-27
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[Presentation] The identification of tumor antigens associated with asbestos-related lung cancer2009
Author(s)
Hanagiri T, Yasuda M, Kuroda K, Shigematsu Y, Baba T, So T, Ono K, Uramoto H, So T, Takenoyama M, Yasumoto K
Organizer
13th World Conference on Lung Cancer
Place of Presentation
W Hotel San Francisco, USA
Year and Date
20090731-0804
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[Presentation] 石綿関連肺癌に対する液性免疫応答の解析2009
Author(s)
安田学, 花桐武志, 黒田耕志, 鬼塚貴光, 重松義紀, 馬場哲郎, 永田好香, 宗哲哉, 小野憲司, 浦本秀隆, 宗知子, 竹之山光広, 安元公正
Organizer
第13回日本がん免疫学会総会
Place of Presentation
北九州国際会議場北九州
Year and Date
20090624-25
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[Presentation] 肺癌に対する新規抗体療法の開発2009
Author(s)
安田学, 花桐武志, 水上真紀子, 塩田広宣, 黒田耕志, 重松義紀, 馬場哲郎, 永田好香, 宗哲哉, 市来嘉伸, 菅谷将一, 浦本秀隆, 宗知子, 大賀丈史, 竹之山光広, 杉尾賢二, 安元公正
Organizer
第26回日本呼吸器外科学会総会
Place of Presentation
西日本総合展示場、北九州国際会議場北九州
Year and Date
20090514-15
