2011 Fiscal Year Final Research Report
New degenerative therapy for cerebral infarction by the functional vascular endothelial progenitor cells
| Project/Area Number |
21591833
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 再生医療 / 脳梗塞 / 脳血管障害 / 脳神経疾患 |
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| Research Abstract |
In this study, we evaluated the therapeutic effect of EPCs with low aldehyde dehydrogenase activity(Alde-Low EPCs) in rats with acute cerebral infarction, and our results provide insight that may help to identify a therapeutic mechanism of EPCs for acute cerebral infarction. The administration of Alde-Low EPCs into rats with acute cerebral infarction results in the accumulation and migration of the Alde-Low EPCs into the infarct area and the subsequent decrease of infarct volume. Moreover, we found that the stromal cell-derived factor-1(SDF-1) and CXC chemokine receptor 4(CXCR4) signaling pathway may regulate the accumulation of Alde-Low EPCs. The transplantation of Alde-Low EPCs may represent a potential treatment strategy for acute cerebral infarction.
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