2011 Fiscal Year Final Research Report
Facial nerve regeneration by suppression of axon growth inhibition signals
| Project/Area Number |
21591838
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOHMURA Eiji 神戸大学, 医学研究科, 教授 (30225388)
KONDOH Takeshi 神戸大学, 医学研究科, 医学研究員 (50273769)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 実験脳外科学 / 顔面神経再生 / 軸索再生阻害因子 / プロテオグリカン |
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| Research Abstract |
The present study demonstrated enhanced recovery of the rat facial nerve function after transection and suturing of the facial nerve by degradation of proteoglycan by chondroitinase injection. The degree of the recovery was, however, only up to 40% of the normal side. Manual stimulation in combination with the chondroitinase injection resulted in additional recovery of about 20%.
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