2011 Fiscal Year Final Research Report
The Investigation of tumor suppression effect of EP4 receptor inhibitors in glioblastoma
| Project/Area Number |
21591839
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAMBE Atsushi 鳥取大学, 医学部, 助教 (70348283)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 膠芽腫 / プロスタグランジンE2受容体EP4 / EGFR |
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| Research Abstract |
We have investigated the tumor suppression effects of selective inhibitors of Prostaglandin E2 receptor, EP4 in human glioblastoma cells. The EP4 expression in malignat gliomas were higher relative to the lower grade gliomas on Immunohistochemistry staining and Western blotting analysis. The selective EP4 receptor inhibitors ONO-AE3-208 and ONO-AE1-328 exhibited the effects of tumor proliferation suppression, tumor invasion suppression and apoptosis induction at high-dose concentrations(50-100uM). They indicated the necessity of further conditional investigations to perform in vivo experiments.
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