2011 Fiscal Year Final Research Report
The effect of CYR61 expression on oncolytic viral treatment for malignant glioma
| Project/Area Number |
21591841
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
SUGIU Kenji 岡山大学, 岡山大学病院, 講師 (40325105)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUROZUMI Kazuhiko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20509608)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
DATE Isao 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70236785)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 悪性グリオーマ / オンコリティックウイルス / CYR61 / 細胞微小環境 / 腫瘍血管新生 |
|---|
| Research Abstract |
We are studying oncolytic viral(OV) therapy as a new therapeutic modality for malignant glioma. In OV therapy-induced changes of the several proangiogenic factors, we confirmed the significant, induction of cysteine-rich protein 61(CYR61) gene expression in tumors treated to OV. We are exploring the influence of angiotome such as CYR61 on OV therapy and continue to make new OV.
|
