2011 Fiscal Year Final Research Report
The basic research for the molecular mechanism of the pathogenesis of cerebral aneurysm
| Project/Area Number |
21591850
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
KAWANO Takayuki 熊本大学, 医学部附属病院, 非常勤診療医師 (50448536)
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| Co-Investigator(Kenkyū-buntansha) |
KURATSU Junichi 熊本大学, 大学院・生命科学研究部, 教授 (20145296)
MORIOKA Motohiro 久留米大学, 医学部, 教授 (20295140)
YANO Shigetoshi 熊本大学, 医学部附属病院, 准教授 (60332871)
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| Project Period (FY) |
2009 – 2011
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| Keywords | シクロオキシゲナーゼ / 脳動脈瘤 |
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| Research Abstract |
Our study shows the expression of COX-2 in the cerebral aneurysm(CA) wall and suggests that this protein is involved in CA pathogenesis. Chronic inflammation due to COX-2 expression is thought to be the main cause of CA rupture, and our study suggests the possibility for medically treating unruptured CAs with a COX-2 inhibitor. In future, the administration of specific prostanoids receptor inhibitors could become the first-choice therapy for patients with unruptured CAs.
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