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2011 Fiscal Year Final Research Report

The basic research for the molecular mechanism of the pathogenesis of cerebral aneurysm

Research Project

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Project/Area Number 21591850
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKumamoto University

Principal Investigator

KAWANO Takayuki  熊本大学, 医学部附属病院, 非常勤診療医師 (50448536)

Co-Investigator(Kenkyū-buntansha) KURATSU Junichi  熊本大学, 大学院・生命科学研究部, 教授 (20145296)
MORIOKA Motohiro  久留米大学, 医学部, 教授 (20295140)
YANO Shigetoshi  熊本大学, 医学部附属病院, 准教授 (60332871)
Project Period (FY) 2009 – 2011
Keywordsシクロオキシゲナーゼ / 脳動脈瘤
Research Abstract

Our study shows the expression of COX-2 in the cerebral aneurysm(CA) wall and suggests that this protein is involved in CA pathogenesis. Chronic inflammation due to COX-2 expression is thought to be the main cause of CA rupture, and our study suggests the possibility for medically treating unruptured CAs with a COX-2 inhibitor. In future, the administration of specific prostanoids receptor inhibitors could become the first-choice therapy for patients with unruptured CAs.

  • Research Products

    (3 results)

All 2010 2009

All Presentation (3 results)

  • [Presentation] 脳動脈瘤の病態に関する免疫組織学的検討:シクロオキシゲナーゼの関与について2010

    • Author(s)
      河野隆幸
    • Organizer
      日本脳神経外科学会総会
    • Place of Presentation
      福岡市
    • Year and Date
      20101027-29
  • [Presentation] Cyclooxygenase is involved in the pathogenesis of cerebral aneurysm in human. Immunohistochemical analysis2010

    • Author(s)
      Takayuki Kawano
    • Organizer
      European Stroke Conference 2010
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-05-27
  • [Presentation] 脳動脈瘤の病態に関する免疫組織学的検討:シクロオキシゲナーゼの関与について2009

    • Author(s)
      河野隆幸
    • Organizer
      日本分子脳神経外科学会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      20090919-20

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Published: 2013-07-31  

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