2011 Fiscal Year Final Research Report
The study of Caveolin-1 and its application in cerebral preconditioning
| Project/Area Number |
21591853
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAHARA Nobutaka 横浜市立大学, 医学研究科, 教授 (60214673)
KANNO Hiroshi 横浜市立大学, 医学研究科, 客員准教授 (40244496)
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| Project Period (FY) |
2009 – 2011
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| Keywords | Caveolin-1 |
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| Research Abstract |
The cerebral ischemic preconditioning didn' t work in Caveolin-1 knockout mice and their cerebrovascular volume in the hippocampi was reduced. Their collateral formation of Willis ring was higher than WT mice, which might be a compensating mechanism. And in the hippocampi of young Caveolin-1 knockout mice, the synapse signaling components were reduced and neurodegenerative changes indicative Alzheimer's disease were seen, which are generally related to aging. Additionally, neuron-targeted Caveolin-1 re-expression in caveolin-1 knockout neurons in vitro decreased amyloid beta protein expression. These data suggests loss of cavolin-1 accelerates neurodegeneration and aging.
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